Coactivator-associated arginine methyltransferase 1: A versatile player in cell differentiation and development

Protein arginine methylation is a common post-translational modification involved in the regulation of various cellular functions. Coactivator-associated arginine methyltransferase 1 (CARM1) is a protein arginine methyltransferase that asymmetrically dimethylates histone H3 and non-histone proteins...

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Autores principales: Ma, Zhongrui, Lyu, Xinxing, Qin, Ning, Liu, Haoyu, Zhang, Mengrui, Lai, Yongchao, Dong, Bo, Lu, Peiyuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Chongqing Medical University 2022
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10404874/
https://www.ncbi.nlm.nih.gov/pubmed/37554200
http://dx.doi.org/10.1016/j.gendis.2022.05.021
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author Ma, Zhongrui
Lyu, Xinxing
Qin, Ning
Liu, Haoyu
Zhang, Mengrui
Lai, Yongchao
Dong, Bo
Lu, Peiyuan
author_facet Ma, Zhongrui
Lyu, Xinxing
Qin, Ning
Liu, Haoyu
Zhang, Mengrui
Lai, Yongchao
Dong, Bo
Lu, Peiyuan
author_sort Ma, Zhongrui
collection PubMed
description Protein arginine methylation is a common post-translational modification involved in the regulation of various cellular functions. Coactivator-associated arginine methyltransferase 1 (CARM1) is a protein arginine methyltransferase that asymmetrically dimethylates histone H3 and non-histone proteins to regulate gene transcription. CARM1 has been found to play important roles in cell differentiation and development, cell cycle progression, autophagy, metabolism, pre-mRNA splicing and transportation, and DNA replication. In this review, we describe the molecular characteristics of CARM1 and summarize its roles in the regulation of cell differentiation and development in mammals.
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spelling pubmed-104048742023-08-08 Coactivator-associated arginine methyltransferase 1: A versatile player in cell differentiation and development Ma, Zhongrui Lyu, Xinxing Qin, Ning Liu, Haoyu Zhang, Mengrui Lai, Yongchao Dong, Bo Lu, Peiyuan Genes Dis Review Article Protein arginine methylation is a common post-translational modification involved in the regulation of various cellular functions. Coactivator-associated arginine methyltransferase 1 (CARM1) is a protein arginine methyltransferase that asymmetrically dimethylates histone H3 and non-histone proteins to regulate gene transcription. CARM1 has been found to play important roles in cell differentiation and development, cell cycle progression, autophagy, metabolism, pre-mRNA splicing and transportation, and DNA replication. In this review, we describe the molecular characteristics of CARM1 and summarize its roles in the regulation of cell differentiation and development in mammals. Chongqing Medical University 2022-06-03 /pmc/articles/PMC10404874/ /pubmed/37554200 http://dx.doi.org/10.1016/j.gendis.2022.05.021 Text en © 2022 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co., Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review Article
Ma, Zhongrui
Lyu, Xinxing
Qin, Ning
Liu, Haoyu
Zhang, Mengrui
Lai, Yongchao
Dong, Bo
Lu, Peiyuan
Coactivator-associated arginine methyltransferase 1: A versatile player in cell differentiation and development
title Coactivator-associated arginine methyltransferase 1: A versatile player in cell differentiation and development
title_full Coactivator-associated arginine methyltransferase 1: A versatile player in cell differentiation and development
title_fullStr Coactivator-associated arginine methyltransferase 1: A versatile player in cell differentiation and development
title_full_unstemmed Coactivator-associated arginine methyltransferase 1: A versatile player in cell differentiation and development
title_short Coactivator-associated arginine methyltransferase 1: A versatile player in cell differentiation and development
title_sort coactivator-associated arginine methyltransferase 1: a versatile player in cell differentiation and development
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10404874/
https://www.ncbi.nlm.nih.gov/pubmed/37554200
http://dx.doi.org/10.1016/j.gendis.2022.05.021
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