Lysine succinylation, the metabolic bridge between cancer and immunity

Lysine succinylation is a naturally occurring post-translational modification (PTM) that regulates the stability and function of proteins. It can be regulated by enzymes such as SIRT5 and SIRT7. Recently, the effect and significance of lysine succinylation in cancer and its implication in immunity h...

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Detalles Bibliográficos
Autores principales: Shen, Rui, Ruan, Hongyun, Lin, Shuye, Liu, Bin, Song, Hang, Li, Lu, Ma, Teng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Chongqing Medical University 2022
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10404875/
https://www.ncbi.nlm.nih.gov/pubmed/37554179
http://dx.doi.org/10.1016/j.gendis.2022.10.028
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author Shen, Rui
Ruan, Hongyun
Lin, Shuye
Liu, Bin
Song, Hang
Li, Lu
Ma, Teng
author_facet Shen, Rui
Ruan, Hongyun
Lin, Shuye
Liu, Bin
Song, Hang
Li, Lu
Ma, Teng
author_sort Shen, Rui
collection PubMed
description Lysine succinylation is a naturally occurring post-translational modification (PTM) that regulates the stability and function of proteins. It can be regulated by enzymes such as SIRT5 and SIRT7. Recently, the effect and significance of lysine succinylation in cancer and its implication in immunity have been extensively explored. Lysine succinylation is involved in the malignant phenotype of cancer cells. Abnormal regulation of lysine succinylation occurs in different cancers, and inhibitors targeting lysine succinylation regulatory enzymes can be used as potential anti-cancer strategies. Therefore, this review focused on the target protein lysine succinylation and its functions in cancer and immunity, in order to provide a reference for finding more potential clinical cancer targets in the future.
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spelling pubmed-104048752023-08-08 Lysine succinylation, the metabolic bridge between cancer and immunity Shen, Rui Ruan, Hongyun Lin, Shuye Liu, Bin Song, Hang Li, Lu Ma, Teng Genes Dis Review Article Lysine succinylation is a naturally occurring post-translational modification (PTM) that regulates the stability and function of proteins. It can be regulated by enzymes such as SIRT5 and SIRT7. Recently, the effect and significance of lysine succinylation in cancer and its implication in immunity have been extensively explored. Lysine succinylation is involved in the malignant phenotype of cancer cells. Abnormal regulation of lysine succinylation occurs in different cancers, and inhibitors targeting lysine succinylation regulatory enzymes can be used as potential anti-cancer strategies. Therefore, this review focused on the target protein lysine succinylation and its functions in cancer and immunity, in order to provide a reference for finding more potential clinical cancer targets in the future. Chongqing Medical University 2022-12-01 /pmc/articles/PMC10404875/ /pubmed/37554179 http://dx.doi.org/10.1016/j.gendis.2022.10.028 Text en © 2022 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co., Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review Article
Shen, Rui
Ruan, Hongyun
Lin, Shuye
Liu, Bin
Song, Hang
Li, Lu
Ma, Teng
Lysine succinylation, the metabolic bridge between cancer and immunity
title Lysine succinylation, the metabolic bridge between cancer and immunity
title_full Lysine succinylation, the metabolic bridge between cancer and immunity
title_fullStr Lysine succinylation, the metabolic bridge between cancer and immunity
title_full_unstemmed Lysine succinylation, the metabolic bridge between cancer and immunity
title_short Lysine succinylation, the metabolic bridge between cancer and immunity
title_sort lysine succinylation, the metabolic bridge between cancer and immunity
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10404875/
https://www.ncbi.nlm.nih.gov/pubmed/37554179
http://dx.doi.org/10.1016/j.gendis.2022.10.028
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