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DNA damage-mediated cellular senescence promotes hand-foot syndrome that can be relieved by thymidine prodrug

Hand-foot syndrome (HFS) is a widely recognized dose-limiting cutaneous toxicity effect of fluoropyrimidine chemotherapy agents that impairs clinical benefits and treatment outcomes. Even though the cause and pathophysiology of HFS are relatively widely reported, how the toxicity of fluoropyrimidine...

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Detalles Bibliográficos
Autores principales:	Yang, Bingxue, Xie, Xinran, Wu, Zhaoyu, Lv, Dazhao, Hu, Jiajun, Chen, Yuyun, Li, Jiaxing, Luo, Shuyue, Li, Jiacheng, Luo, Jie, Zhang, Shiyi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Chongqing Medical University 2022
Materias:	Full Length Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10404883/ https://www.ncbi.nlm.nih.gov/pubmed/37554214 http://dx.doi.org/10.1016/j.gendis.2022.10.004

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