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Multisensory integration in the mammalian brain: diversity and flexibility in health and disease
Multisensory integration (MSI) occurs in a variety of brain areas, spanning cortical and subcortical regions. In traditional studies on sensory processing, the sensory cortices have been considered for processing sensory information in a modality-specific manner. The sensory cortices, however, send...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10404930/ https://www.ncbi.nlm.nih.gov/pubmed/37545309 http://dx.doi.org/10.1098/rstb.2022.0338 |
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author | Choi, Ilsong Demir, Ilayda Oh, Seungmi Lee, Seung-Hee |
author_facet | Choi, Ilsong Demir, Ilayda Oh, Seungmi Lee, Seung-Hee |
author_sort | Choi, Ilsong |
collection | PubMed |
description | Multisensory integration (MSI) occurs in a variety of brain areas, spanning cortical and subcortical regions. In traditional studies on sensory processing, the sensory cortices have been considered for processing sensory information in a modality-specific manner. The sensory cortices, however, send the information to other cortical and subcortical areas, including the higher association cortices and the other sensory cortices, where the multiple modality inputs converge and integrate to generate a meaningful percept. This integration process is neither simple nor fixed because these brain areas interact with each other via complicated circuits, which can be modulated by numerous internal and external conditions. As a result, dynamic MSI makes multisensory decisions flexible and adaptive in behaving animals. Impairments in MSI occur in many psychiatric disorders, which may result in an altered perception of the multisensory stimuli and an abnormal reaction to them. This review discusses the diversity and flexibility of MSI in mammals, including humans, primates and rodents, as well as the brain areas involved. It further explains how such flexibility influences perceptual experiences in behaving animals in both health and disease. This article is part of the theme issue ‘Decision and control processes in multisensory perception’. |
format | Online Article Text |
id | pubmed-10404930 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | The Royal Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-104049302023-08-08 Multisensory integration in the mammalian brain: diversity and flexibility in health and disease Choi, Ilsong Demir, Ilayda Oh, Seungmi Lee, Seung-Hee Philos Trans R Soc Lond B Biol Sci Articles Multisensory integration (MSI) occurs in a variety of brain areas, spanning cortical and subcortical regions. In traditional studies on sensory processing, the sensory cortices have been considered for processing sensory information in a modality-specific manner. The sensory cortices, however, send the information to other cortical and subcortical areas, including the higher association cortices and the other sensory cortices, where the multiple modality inputs converge and integrate to generate a meaningful percept. This integration process is neither simple nor fixed because these brain areas interact with each other via complicated circuits, which can be modulated by numerous internal and external conditions. As a result, dynamic MSI makes multisensory decisions flexible and adaptive in behaving animals. Impairments in MSI occur in many psychiatric disorders, which may result in an altered perception of the multisensory stimuli and an abnormal reaction to them. This review discusses the diversity and flexibility of MSI in mammals, including humans, primates and rodents, as well as the brain areas involved. It further explains how such flexibility influences perceptual experiences in behaving animals in both health and disease. This article is part of the theme issue ‘Decision and control processes in multisensory perception’. The Royal Society 2023-09-25 2023-08-07 /pmc/articles/PMC10404930/ /pubmed/37545309 http://dx.doi.org/10.1098/rstb.2022.0338 Text en © 2023 The Authors. https://creativecommons.org/licenses/by/4.0/Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, provided the original author and source are credited. |
spellingShingle | Articles Choi, Ilsong Demir, Ilayda Oh, Seungmi Lee, Seung-Hee Multisensory integration in the mammalian brain: diversity and flexibility in health and disease |
title | Multisensory integration in the mammalian brain: diversity and flexibility in health and disease |
title_full | Multisensory integration in the mammalian brain: diversity and flexibility in health and disease |
title_fullStr | Multisensory integration in the mammalian brain: diversity and flexibility in health and disease |
title_full_unstemmed | Multisensory integration in the mammalian brain: diversity and flexibility in health and disease |
title_short | Multisensory integration in the mammalian brain: diversity and flexibility in health and disease |
title_sort | multisensory integration in the mammalian brain: diversity and flexibility in health and disease |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10404930/ https://www.ncbi.nlm.nih.gov/pubmed/37545309 http://dx.doi.org/10.1098/rstb.2022.0338 |
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