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The organization and function of the Golgi apparatus in dendrite development and neurological disorders

Dendrites are specialized neuronal compartments that sense, integrate and transfer information in the neural network. Their development is tightly controlled and abnormal dendrite morphogenesis is strongly linked to neurological disorders. While dendritic morphology ranges from relatively simple to...

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Autores principales: Chen, Meilan, Xu, Lu, Wu, Yi, Soba, Peter, Hu, Chun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Chongqing Medical University 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10404969/
https://www.ncbi.nlm.nih.gov/pubmed/37554209
http://dx.doi.org/10.1016/j.gendis.2022.11.009
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author Chen, Meilan
Xu, Lu
Wu, Yi
Soba, Peter
Hu, Chun
author_facet Chen, Meilan
Xu, Lu
Wu, Yi
Soba, Peter
Hu, Chun
author_sort Chen, Meilan
collection PubMed
description Dendrites are specialized neuronal compartments that sense, integrate and transfer information in the neural network. Their development is tightly controlled and abnormal dendrite morphogenesis is strongly linked to neurological disorders. While dendritic morphology ranges from relatively simple to extremely complex for a specified neuron, either requires a functional secretory pathway to continually replenish proteins and lipids to meet dendritic growth demands. The Golgi apparatus occupies the center of the secretory pathway and is regulating posttranslational modifications, sorting, transport, and signal transduction, as well as acting as a non-centrosomal microtubule organization center. The neuronal Golgi apparatus shares common features with Golgi in other eukaryotic cell types but also forms distinct structures known as Golgi outposts that specifically localize in dendrites. However, the organization and function of Golgi in dendrite development and its impact on neurological disorders is just emerging and so far lacks a systematic summary. We describe the organization of the Golgi apparatus in neurons, review the current understanding of Golgi function in dendritic morphogenesis, and discuss the current challenges and future directions.
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spelling pubmed-104049692023-08-08 The organization and function of the Golgi apparatus in dendrite development and neurological disorders Chen, Meilan Xu, Lu Wu, Yi Soba, Peter Hu, Chun Genes Dis Review Article Dendrites are specialized neuronal compartments that sense, integrate and transfer information in the neural network. Their development is tightly controlled and abnormal dendrite morphogenesis is strongly linked to neurological disorders. While dendritic morphology ranges from relatively simple to extremely complex for a specified neuron, either requires a functional secretory pathway to continually replenish proteins and lipids to meet dendritic growth demands. The Golgi apparatus occupies the center of the secretory pathway and is regulating posttranslational modifications, sorting, transport, and signal transduction, as well as acting as a non-centrosomal microtubule organization center. The neuronal Golgi apparatus shares common features with Golgi in other eukaryotic cell types but also forms distinct structures known as Golgi outposts that specifically localize in dendrites. However, the organization and function of Golgi in dendrite development and its impact on neurological disorders is just emerging and so far lacks a systematic summary. We describe the organization of the Golgi apparatus in neurons, review the current understanding of Golgi function in dendritic morphogenesis, and discuss the current challenges and future directions. Chongqing Medical University 2022-12-20 /pmc/articles/PMC10404969/ /pubmed/37554209 http://dx.doi.org/10.1016/j.gendis.2022.11.009 Text en © 2022 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co., Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review Article
Chen, Meilan
Xu, Lu
Wu, Yi
Soba, Peter
Hu, Chun
The organization and function of the Golgi apparatus in dendrite development and neurological disorders
title The organization and function of the Golgi apparatus in dendrite development and neurological disorders
title_full The organization and function of the Golgi apparatus in dendrite development and neurological disorders
title_fullStr The organization and function of the Golgi apparatus in dendrite development and neurological disorders
title_full_unstemmed The organization and function of the Golgi apparatus in dendrite development and neurological disorders
title_short The organization and function of the Golgi apparatus in dendrite development and neurological disorders
title_sort organization and function of the golgi apparatus in dendrite development and neurological disorders
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10404969/
https://www.ncbi.nlm.nih.gov/pubmed/37554209
http://dx.doi.org/10.1016/j.gendis.2022.11.009
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