Isoniazid resistance-conferring mutations are associated with highly variable phenotypic resistance

BACKGROUND: High-dose isoniazid is recommended in the 9–12 months short-course regimen for multidrug-resistant tuberculosis with inhA mutation. However, there is insufficient evidence to support the assumption of genotypic-phenotypic concordance. This study aimed to identify the genetic mutations as...

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Detalles Bibliográficos
Autores principales: Lale Ngema, Senamile, Dookie, Navisha, Perumal, Rubeshan, Nandlal, Louansha, Naicker, Nikita, Peter Letsoalo, Marothi, O'Donnell, Max, Khan, Azraa, Padayatchi, Nesri, Naidoo, Kogieleum
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10405055/
https://www.ncbi.nlm.nih.gov/pubmed/37554582
http://dx.doi.org/10.1016/j.jctube.2023.100387

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10405055/
https://www.ncbi.nlm.nih.gov/pubmed/37554582
http://dx.doi.org/10.1016/j.jctube.2023.100387

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