Cargando…

Isoniazid resistance-conferring mutations are associated with highly variable phenotypic resistance

BACKGROUND: High-dose isoniazid is recommended in the 9–12 months short-course regimen for multidrug-resistant tuberculosis with inhA mutation. However, there is insufficient evidence to support the assumption of genotypic-phenotypic concordance. This study aimed to identify the genetic mutations as...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lale Ngema, Senamile, Dookie, Navisha, Perumal, Rubeshan, Nandlal, Louansha, Naicker, Nikita, Peter Letsoalo, Marothi, O'Donnell, Max, Khan, Azraa, Padayatchi, Nesri, Naidoo, Kogieleum
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10405055/ https://www.ncbi.nlm.nih.gov/pubmed/37554582 http://dx.doi.org/10.1016/j.jctube.2023.100387

Ejemplares similares

Mycobacterium tuberculosis Intra-Host Evolution Among Drug-Resistant Tuberculosis Patients Failing Treatment
por: Perumal, Rubeshan, et al.
Publicado: (2023)

Application of Next Generation Sequencing for Diagnosis and Clinical Management of Drug-Resistant Tuberculosis: Updates on Recent Developments in the Field
por: Dookie, Navisha, et al.
Publicado: (2022)

Rapid Molecular Assays for the Diagnosis of Drug-Resistant Tuberculosis
por: Nandlal, Louansha, et al.
Publicado: (2022)

Evolution of drug resistance in Mycobacterium tuberculosis: a review on the molecular determinants of resistance and implications for personalized care
por: Dookie, Navisha, et al.
Publicado: (2018)

Individualized Treatment of Multidrug-resistant Tuberculosis Using Whole-Genome Sequencing and Expanded Drug-Susceptibility Testing
por: Dookie, Navisha, et al.
Publicado: (2020)

Higher plasma interleukin − 6 levels are associated with lung cavitation in drug-resistant tuberculosis
por: Maseko, Thando Glory, et al.
Publicado: (2023)

TB epidemiology: where are the young women? Know your tuberculosis epidemic, know your response
por: Perumal, Rubeshan, et al.
Publicado: (2018)

Understanding the Profile of Tuberculosis and Human Immunodeficiency Virus Coinfection: Insights from Expanded HIV Surveillance at a Tuberculosis Facility in Durban, South Africa
por: Perumal, Rubeshan, et al.
Publicado: (2014)

Detection of differentially culturable tubercle bacteria in sputum from drug-resistant tuberculosis patients
por: Gordhan, Bhavna G., et al.
Publicado: (2022)

Recurrent tuberculosis among HIV-coinfected patients: a case series from KwaZulu-Natal
por: Naidoo, Kogieleum, et al.
Publicado: (2018)

The whole is greater than the sum of the parts: Recognising missed opportunities for an optimal response to the rapidly maturing TB-HIV co-epidemic in South Africa
por: Perumal, Rubeshan, et al.
Publicado: (2009)

INSTIs for the management of HIV-associated TB (INSIGHT study): a phase 2b study to evaluate the efficacy, safety and pharmacokinetics of a combination of bictegravir, emtricitabine and tenofovir alafenamide fumarate for the treatment of HIV-1 infection in patients with drug-susceptible tuberculosis on a rifampicin-based treatment regimen: a phase 2b open-label randomised controlled trial
por: Naidoo, Anushka, et al.
Publicado: (2022)

Metformin Increases Cell Viability and Regulates Pro-Inflammatory Response to Mtb
por: Naicker, Nikita, et al.
Publicado: (2023)

Recurrent Subclinical Tuberculosis Among Antiretroviral Therapy–Accessing Participants: Incidence, Clinical Course, and Outcomes( )
por: Naidoo, Kogieleum, et al.
Publicado: (2022)

Advances in tuberculosis control during the past decade
por: Naidoo, Kogieleum, et al.
Publicado: (2023)

HIV-Associated Tuberculosis
por: Naidoo, Kogieleum, et al.
Publicado: (2011)

NK cell phenotypic profile during active TB in people living with HIV-evolution during TB treatment and implications for bacterial clearance and disease severity
por: Maseko, Thando Glory, et al.
Publicado: (2023)

Hyperbilirubinemia in atazanavir-treated human immunodeficiency virus-infected patients: the impact of the UGT1A1*28 allele
por: Naidoo, Anushka, et al.
Publicado: (2017)

Long COVID: An approach to clinical assessment and management in primary care
por: Perumal, Rubeshan, et al.
Publicado: (2023)

Nephrotic Syndrome in South African Children: Changing Perspectives in the New Millennium
por: Nandlal, Louansha, et al.
Publicado: (2019)

Tuberculosis: treatment failure, or failure to treat? Lessons from India and South Africa
por: Padayatchi, Nesri, et al.
Publicado: (2019)

Quality of TB care among people living with HIV: Gaps and solutions
por: Naidoo, Kogieleum, et al.
Publicado: (2019)

Treatment Outcomes for Extensively Drug-Resistant Tuberculosis and HIV Co-infection
por: O’Donnell, Max R., et al.
Publicado: (2013)

Moxifloxacin resistance in the F15/LAM4/KZN extensively drug-resistant strain of Mycobacterium tuberculosis
por: Dookie, Navisha, et al.
Publicado: (2014)

Mechanisms of first-line antimicrobial resistance in multi-drug and extensively drug resistant strains of Mycobacterium tuberculosis in KwaZulu-Natal, South Africa
por: Dookie, Navisha, et al.
Publicado: (2016)

Extensively Drug-Resistant Tuberculosis in Women, KwaZulu-Natal, South Africa
por: O’Donnell, Max R., et al.
Publicado: (2011)

Mandatory COVID-19 Vaccination: Lessons from Tuberculosis and HIV
por: Mtimkulu-Eyde, Lynette, et al.
Publicado: (2022)

Bedaquiline resistance in drug-resistant tuberculosis HIV co-infected patients
por: Nimmo, Camus, et al.
Publicado: (2020)

Dynamic needs and challenges of people with drug-resistant tuberculosis and HIV in South Africa: a qualitative study
por: Daftary, Amrita, et al.
Publicado: (2021)

Metformin as Host-Directed Therapy for TB Treatment: Scoping Review
por: Naicker, Nikita, et al.
Publicado: (2020)

Prevalence of Primary Hypertension and Risk Factors in Grade XII Learners in KwaZulu-Natal, South Africa
por: Bhimma, Rajendra, et al.
Publicado: (2018)

The prevalence of chronic kidney disease in South Africa - limitations of studies comparing prevalence with sub-Saharan Africa, Africa, and globally
por: Hariparshad, Sudesh, et al.
Publicado: (2023)

Population-level emergence of bedaquiline and clofazimine resistance-associated variants among patients with drug-resistant tuberculosis in southern Africa: a phenotypic and phylogenetic analysis
por: Nimmo, Camus, et al.
Publicado: (2020)

Addressing challenges in scaling up TB and HIV treatment integration in rural primary healthcare clinics in South Africa (SUTHI): a cluster randomized controlled trial protocol
por: Naidoo, Kogieleum, et al.
Publicado: (2017)

Correction to: Addressing challenges in scaling up TB and HIV treatment integration in rural primary healthcare clinics in South Africa (SUTHI): a cluster randomized controlled trial protocol
por: Naidoo, Kogieleum, et al.
Publicado: (2019)

Adaptive evaluation of mHealth and conventional adherence support interventions to optimize outcomes with new treatment regimens for drug-resistant tuberculosis and HIV in South Africa (ADAP-TIV): Study protocol for an adaptive randomized controlled trial
por: Ross, Jesse E, et al.
Publicado: (2023)

Adaptive evaluation of mHealth and conventional adherence support interventions to optimize outcomes with new treatment regimens for drug-resistant tuberculosis and HIV in South Africa (ADAP-TIV): study protocol for an adaptive randomized controlled trial
por: Ross, Jesse, et al.
Publicado: (2023)

Effect of Inflammatory Cytokines/Chemokines on Pulmonary Tuberculosis Culture Conversion and Disease Severity in HIV-Infected and -Uninfected Individuals From South Africa
por: Rambaran, Santhuri, et al.
Publicado: (2021)

Impact of pretreatment low-abundance HIV-1 drug-resistant variants on virological failure among HIV-1/TB-co-infected individuals
por: Chimukangara, Benjamin, et al.
Publicado: (2020)

Opportunities and limitations of genomics for diagnosing bedaquiline-resistant tuberculosis: an individual isolate metaanalysis
por: Nimmo, Camus, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_1otmumurrp4nkamf00sbfjcord