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Targeting ITGB4/SOX2-driven lung cancer stem cells using proteasome inhibitors

This study investigates the role of integrin β4 (ITGB4) and stemness-associated factor SOX2 in platinum resistance in lung squamous cell carcinoma (LUSC). The expression of SOX2 and ITGB4 is found to be high in all LUSC subtypes, but the impact of ITGB4 expression on overall patient survival varies...

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Detalles Bibliográficos
Autores principales:	Guo, Linlin, Mohanty, Atish, Singhal, Sharad, Srivastava, Saumya, Nam, Arin, Warden, Charles, Ramisetty, Sravani, Yuan, Yate-Ching, Cho, Hyejin, Wu, Xiwei, Li, Aimin, Vohra, Manik, Saladi, Srinivas Vinod, Wheeler, Deric, Arvanitis, Leonidas, Massarelli, Erminia, Kulkarni, Prakash, Zeng, Yiming, Salgia, Ravi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10405066/ https://www.ncbi.nlm.nih.gov/pubmed/37554452 http://dx.doi.org/10.1016/j.isci.2023.107302

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