Tomatidine targets ATF4-dependent signaling and induces ferroptosis to limit pancreatic cancer progression

Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with high metastasis and therapeutic resistance. Activating transcription factor 4 (ATF4), a master regulator of cellular stress, is exploited by cancer cells to survive. Prior research and data reported provide evidence that high ATF4...

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Detalles Bibliográficos
Autores principales: Mukherjee, Debasmita, Chakraborty, Srija, Bercz, Lena, D’Alesio, Liliana, Wedig, Jessica, Torok, Molly A., Pfau, Timothy, Lathrop, Hannah, Jasani, Shrina, Guenther, Abigail, McGue, Jake, Adu-Ampratwum, Daniel, Fuchs, James R., Frankel, Timothy L., Pietrzak, Maciej, Culp, Stacey, Strohecker, Anne M., Skardal, Aleksander, Mace, Thomas A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10405072/
https://www.ncbi.nlm.nih.gov/pubmed/37554459
http://dx.doi.org/10.1016/j.isci.2023.107408

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