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Nomogram based on clinical characteristics for predicting overall survival in gastric cancer patients with preoperative anemia
BACKGROUND: Preoperative anemia is associated with increased postoperative morbidity and mortality and increased perioperative transfusion risk. For surgical patients, this affects physical and cognitive ability and quality of life, but it is an important and modifiable risk factor. AIM: To determin...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Baishideng Publishing Group Inc
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10405121/ https://www.ncbi.nlm.nih.gov/pubmed/37555125 http://dx.doi.org/10.4240/wjgs.v15.i7.1375 |
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author | Long, Yan Zhou, Xiao-Lu Zhang, Cheng-Long Wang, Ya-Nan Pan, Wen-Sheng |
author_facet | Long, Yan Zhou, Xiao-Lu Zhang, Cheng-Long Wang, Ya-Nan Pan, Wen-Sheng |
author_sort | Long, Yan |
collection | PubMed |
description | BACKGROUND: Preoperative anemia is associated with increased postoperative morbidity and mortality and increased perioperative transfusion risk. For surgical patients, this affects physical and cognitive ability and quality of life, but it is an important and modifiable risk factor. AIM: To determine the effect of preoperative anemia on the prognosis of gastric cancer (GC) patients and generate a prognostic nomogram to predict the postoperative overall survival (OS) of GC patients with preoperative anemia. METHODS: Clinicopathological and follow-up data of GC patients treated at Zhejiang Provincial People's Hospital (China) from 2010 to 2015 were collected. Independent prognostic factors were screened by univariate and multivariate Cox regression analyses. Then, these factors were used to construct a nomogram to predict 1-, 3-, and 5-year postoperative OS in preoperative anemic GC patients. The nomogram was assessed by calibration curves, receiver operating characteristic (ROC) curves, and decision curve analysis (DCA). RESULTS: Nine hundred and sixty GC patients were divided into two groups (preoperatively anemic and nonanemic), and postoperative survival analysis was performed on both groups, yielding a shorter postoperative survival for preoperatively anemic patients than for nonanemic patients. A total of 347 GC patients with preoperative anemia were included. Age, preoperative alpha-fetoprotein level, monocyte count, lymphocyte count, clinicopathological stage, liver metastasis, and GC type were identified as independent prognostic factors for OS. The area under the ROC curve (AUC) of the nomogram for predicting 1-, 3-, and 5-year OS was 0.831, 0.845, and 0.840, respectively, for the training cohort, and the corresponding AUC values in the validation cohort were 0.827, 0.829, and 0.812, respectively. Calibration curves and DCA indicated good performance of the nomogram. CONCLUSION: In all, we have successfully produced and verified a useful nomogram for predicting OS in GC patients with preoperative anemia. This nomogram based on a variety of clinicopathological indices can provide an effective prognostic assessment and help clinicians choose an appropriate treatment strategy for GC patients with preoperative anemia. |
format | Online Article Text |
id | pubmed-10405121 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Baishideng Publishing Group Inc |
record_format | MEDLINE/PubMed |
spelling | pubmed-104051212023-08-08 Nomogram based on clinical characteristics for predicting overall survival in gastric cancer patients with preoperative anemia Long, Yan Zhou, Xiao-Lu Zhang, Cheng-Long Wang, Ya-Nan Pan, Wen-Sheng World J Gastrointest Surg Retrospective Study BACKGROUND: Preoperative anemia is associated with increased postoperative morbidity and mortality and increased perioperative transfusion risk. For surgical patients, this affects physical and cognitive ability and quality of life, but it is an important and modifiable risk factor. AIM: To determine the effect of preoperative anemia on the prognosis of gastric cancer (GC) patients and generate a prognostic nomogram to predict the postoperative overall survival (OS) of GC patients with preoperative anemia. METHODS: Clinicopathological and follow-up data of GC patients treated at Zhejiang Provincial People's Hospital (China) from 2010 to 2015 were collected. Independent prognostic factors were screened by univariate and multivariate Cox regression analyses. Then, these factors were used to construct a nomogram to predict 1-, 3-, and 5-year postoperative OS in preoperative anemic GC patients. The nomogram was assessed by calibration curves, receiver operating characteristic (ROC) curves, and decision curve analysis (DCA). RESULTS: Nine hundred and sixty GC patients were divided into two groups (preoperatively anemic and nonanemic), and postoperative survival analysis was performed on both groups, yielding a shorter postoperative survival for preoperatively anemic patients than for nonanemic patients. A total of 347 GC patients with preoperative anemia were included. Age, preoperative alpha-fetoprotein level, monocyte count, lymphocyte count, clinicopathological stage, liver metastasis, and GC type were identified as independent prognostic factors for OS. The area under the ROC curve (AUC) of the nomogram for predicting 1-, 3-, and 5-year OS was 0.831, 0.845, and 0.840, respectively, for the training cohort, and the corresponding AUC values in the validation cohort were 0.827, 0.829, and 0.812, respectively. Calibration curves and DCA indicated good performance of the nomogram. CONCLUSION: In all, we have successfully produced and verified a useful nomogram for predicting OS in GC patients with preoperative anemia. This nomogram based on a variety of clinicopathological indices can provide an effective prognostic assessment and help clinicians choose an appropriate treatment strategy for GC patients with preoperative anemia. Baishideng Publishing Group Inc 2023-07-27 2023-07-27 /pmc/articles/PMC10405121/ /pubmed/37555125 http://dx.doi.org/10.4240/wjgs.v15.i7.1375 Text en ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
spellingShingle | Retrospective Study Long, Yan Zhou, Xiao-Lu Zhang, Cheng-Long Wang, Ya-Nan Pan, Wen-Sheng Nomogram based on clinical characteristics for predicting overall survival in gastric cancer patients with preoperative anemia |
title | Nomogram based on clinical characteristics for predicting overall survival in gastric cancer patients with preoperative anemia |
title_full | Nomogram based on clinical characteristics for predicting overall survival in gastric cancer patients with preoperative anemia |
title_fullStr | Nomogram based on clinical characteristics for predicting overall survival in gastric cancer patients with preoperative anemia |
title_full_unstemmed | Nomogram based on clinical characteristics for predicting overall survival in gastric cancer patients with preoperative anemia |
title_short | Nomogram based on clinical characteristics for predicting overall survival in gastric cancer patients with preoperative anemia |
title_sort | nomogram based on clinical characteristics for predicting overall survival in gastric cancer patients with preoperative anemia |
topic | Retrospective Study |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10405121/ https://www.ncbi.nlm.nih.gov/pubmed/37555125 http://dx.doi.org/10.4240/wjgs.v15.i7.1375 |
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