Binding of a Pyrene-Based Fluorescent Amyloid Ligand to Transthyretin: A Combined Crystallographic and Molecular Dynamics Study

[Image: see text] Misfolding and aggregation of transthyretin (TTR) cause several amyloid diseases. Besides being an amyloidogenic protein, TTR has an affinity for bicyclic small-molecule ligands in its thyroxine (T4) binding site. One class of TTR ligands are trans-stilbenes. The trans-stilbene sca...

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Detalles Bibliográficos
Autores principales: Thi Minh, Nghia Nguyen, Begum, Afshan, Zhang, Jun, Leira, Petter, Todarwal, Yogesh, Linares, Mathieu, Norman, Patrick, Derbyshire, Dean, von Castelmur, Eleonore, Lindgren, Mikael, Hammarström, Per, König, Carolin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10405211/
https://www.ncbi.nlm.nih.gov/pubmed/37477604
http://dx.doi.org/10.1021/acs.jpcb.3c02147

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