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Experimental training in molecular pharmacology education based on drug–target interactions

INTRODUCTION: Drug development has been challenged by the dual drawbacks involving unpredictable disease outcomes and drug resistance, which has placed greater demands on pharmacology education. Molecular pharmacology, as a frontier crossover field of pharmacology, focuses on the research of new dru...

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Autores principales: Ge, Luna, Cheng, Kai, Zhang, Yuang, Li, Junling, Chen, Wei, Song, Guanhua, Wang, Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10405239/
https://www.ncbi.nlm.nih.gov/pubmed/37548279
http://dx.doi.org/10.1002/prp2.1118
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author Ge, Luna
Cheng, Kai
Zhang, Yuang
Li, Junling
Chen, Wei
Song, Guanhua
Wang, Lin
author_facet Ge, Luna
Cheng, Kai
Zhang, Yuang
Li, Junling
Chen, Wei
Song, Guanhua
Wang, Lin
author_sort Ge, Luna
collection PubMed
description INTRODUCTION: Drug development has been challenged by the dual drawbacks involving unpredictable disease outcomes and drug resistance, which has placed greater demands on pharmacology education. Molecular pharmacology, as a frontier crossover field of pharmacology, focuses on the research of new drugs and targets. However, due to the lack of a systematic experimental training system, molecular pharmacology has not made a corresponding contribution in promoting the training of innovative talent in pharmacology. We aim to establish an experimental training program suitable for molecular pharmacology to improve students' ability to engage in drug development in future. METHODS: Based on the feasibility of drug–target projects, a comprehensive training program containing molecular docking, target stability experiment, and fluorescent probe detection of protein expression in living cells and mice was conducted among 20 pharmacy graduate students. The experimental training was assessed by the experimental training report and the student recognition questionnaires. RESULTS: All 20 students mastered the experimental principles and operations required for the training program. The experimental reports proved that the students were in good command of the experimental principles, operations and applications. The results of the Likert questionnaire indicated that the training program promoted the understanding of the drug research process and increased motivation to learn. CONCLUSION: The designed experimental training program has a positive effect on the training of pharmacology talents, and can be implemented as a part of molecular pharmacology education.
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spelling pubmed-104052392023-08-08 Experimental training in molecular pharmacology education based on drug–target interactions Ge, Luna Cheng, Kai Zhang, Yuang Li, Junling Chen, Wei Song, Guanhua Wang, Lin Pharmacol Res Perspect Pharmacology Education and Innovation INTRODUCTION: Drug development has been challenged by the dual drawbacks involving unpredictable disease outcomes and drug resistance, which has placed greater demands on pharmacology education. Molecular pharmacology, as a frontier crossover field of pharmacology, focuses on the research of new drugs and targets. However, due to the lack of a systematic experimental training system, molecular pharmacology has not made a corresponding contribution in promoting the training of innovative talent in pharmacology. We aim to establish an experimental training program suitable for molecular pharmacology to improve students' ability to engage in drug development in future. METHODS: Based on the feasibility of drug–target projects, a comprehensive training program containing molecular docking, target stability experiment, and fluorescent probe detection of protein expression in living cells and mice was conducted among 20 pharmacy graduate students. The experimental training was assessed by the experimental training report and the student recognition questionnaires. RESULTS: All 20 students mastered the experimental principles and operations required for the training program. The experimental reports proved that the students were in good command of the experimental principles, operations and applications. The results of the Likert questionnaire indicated that the training program promoted the understanding of the drug research process and increased motivation to learn. CONCLUSION: The designed experimental training program has a positive effect on the training of pharmacology talents, and can be implemented as a part of molecular pharmacology education. John Wiley and Sons Inc. 2023-08-07 /pmc/articles/PMC10405239/ /pubmed/37548279 http://dx.doi.org/10.1002/prp2.1118 Text en © 2023 The Authors. Pharmacology Research & Perspectives published by British Pharmacological Society and American Society for Pharmacology and Experimental Therapeutics and John Wiley & Sons Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Pharmacology Education and Innovation
Ge, Luna
Cheng, Kai
Zhang, Yuang
Li, Junling
Chen, Wei
Song, Guanhua
Wang, Lin
Experimental training in molecular pharmacology education based on drug–target interactions
title Experimental training in molecular pharmacology education based on drug–target interactions
title_full Experimental training in molecular pharmacology education based on drug–target interactions
title_fullStr Experimental training in molecular pharmacology education based on drug–target interactions
title_full_unstemmed Experimental training in molecular pharmacology education based on drug–target interactions
title_short Experimental training in molecular pharmacology education based on drug–target interactions
title_sort experimental training in molecular pharmacology education based on drug–target interactions
topic Pharmacology Education and Innovation
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10405239/
https://www.ncbi.nlm.nih.gov/pubmed/37548279
http://dx.doi.org/10.1002/prp2.1118
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