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Polysubstance addiction patterns among 7,989 individuals with cocaine use disorder
To characterize polysubstance addiction (PSA) patterns of cocaine use disorder (CoUD), we performed a latent class analysis (LCA) in 7,989 participants with a lifetime DSM-5 diagnosis of CoUD. This analysis identified three PSA subgroups among CoUD participants (i.e., low, 17%; intermediate, 38%; hi...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10405253/ https://www.ncbi.nlm.nih.gov/pubmed/37554454 http://dx.doi.org/10.1016/j.isci.2023.107336 |
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author | Stiltner, Brendan Pietrzak, Robert H. Tylee, Daniel S. Nunez, Yaira Z. Adhikari, Keyrun Kranzler, Henry R. Gelernter, Joel Polimanti, Renato |
author_facet | Stiltner, Brendan Pietrzak, Robert H. Tylee, Daniel S. Nunez, Yaira Z. Adhikari, Keyrun Kranzler, Henry R. Gelernter, Joel Polimanti, Renato |
author_sort | Stiltner, Brendan |
collection | PubMed |
description | To characterize polysubstance addiction (PSA) patterns of cocaine use disorder (CoUD), we performed a latent class analysis (LCA) in 7,989 participants with a lifetime DSM-5 diagnosis of CoUD. This analysis identified three PSA subgroups among CoUD participants (i.e., low, 17%; intermediate, 38%; high, 45%). While these subgroups varied by age, sex, and racial-ethnic distribution (p < 0.001), there was no difference with respect to education or income (p > 0.05). After accounting for sex, age, and race-ethnicity, the CoUD subgroup with high PSA had higher odds of antisocial personality disorder (OR = 21.96 vs. 6.39, difference-p = 8.08✕10(−6)), agoraphobia (OR = 4.58 vs. 2.05, difference-p = 7.04✕10(−4)), mixed bipolar episode (OR = 10.36 vs. 2.61, difference-p = 7.04✕10(−4)), posttraumatic stress disorder (OR = 11.54 vs. 5.86, difference-p = 2.67✕10(−4)), antidepressant medication use (OR = 13.49 vs. 8.02, difference-p = 1.42✕10(−4)), and sexually transmitted diseases (OR = 5.92 vs. 3.38, difference-p = 1.81✕10(−5)) than the low-PSA CoUD subgroup. These findings underscore the importance of modeling PSA severity and comorbidities when examining the clinical, molecular, and neuroimaging correlates of CoUD. |
format | Online Article Text |
id | pubmed-10405253 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-104052532023-08-08 Polysubstance addiction patterns among 7,989 individuals with cocaine use disorder Stiltner, Brendan Pietrzak, Robert H. Tylee, Daniel S. Nunez, Yaira Z. Adhikari, Keyrun Kranzler, Henry R. Gelernter, Joel Polimanti, Renato iScience Article To characterize polysubstance addiction (PSA) patterns of cocaine use disorder (CoUD), we performed a latent class analysis (LCA) in 7,989 participants with a lifetime DSM-5 diagnosis of CoUD. This analysis identified three PSA subgroups among CoUD participants (i.e., low, 17%; intermediate, 38%; high, 45%). While these subgroups varied by age, sex, and racial-ethnic distribution (p < 0.001), there was no difference with respect to education or income (p > 0.05). After accounting for sex, age, and race-ethnicity, the CoUD subgroup with high PSA had higher odds of antisocial personality disorder (OR = 21.96 vs. 6.39, difference-p = 8.08✕10(−6)), agoraphobia (OR = 4.58 vs. 2.05, difference-p = 7.04✕10(−4)), mixed bipolar episode (OR = 10.36 vs. 2.61, difference-p = 7.04✕10(−4)), posttraumatic stress disorder (OR = 11.54 vs. 5.86, difference-p = 2.67✕10(−4)), antidepressant medication use (OR = 13.49 vs. 8.02, difference-p = 1.42✕10(−4)), and sexually transmitted diseases (OR = 5.92 vs. 3.38, difference-p = 1.81✕10(−5)) than the low-PSA CoUD subgroup. These findings underscore the importance of modeling PSA severity and comorbidities when examining the clinical, molecular, and neuroimaging correlates of CoUD. Elsevier 2023-07-16 /pmc/articles/PMC10405253/ /pubmed/37554454 http://dx.doi.org/10.1016/j.isci.2023.107336 Text en © 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Article Stiltner, Brendan Pietrzak, Robert H. Tylee, Daniel S. Nunez, Yaira Z. Adhikari, Keyrun Kranzler, Henry R. Gelernter, Joel Polimanti, Renato Polysubstance addiction patterns among 7,989 individuals with cocaine use disorder |
title | Polysubstance addiction patterns among 7,989 individuals with cocaine use disorder |
title_full | Polysubstance addiction patterns among 7,989 individuals with cocaine use disorder |
title_fullStr | Polysubstance addiction patterns among 7,989 individuals with cocaine use disorder |
title_full_unstemmed | Polysubstance addiction patterns among 7,989 individuals with cocaine use disorder |
title_short | Polysubstance addiction patterns among 7,989 individuals with cocaine use disorder |
title_sort | polysubstance addiction patterns among 7,989 individuals with cocaine use disorder |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10405253/ https://www.ncbi.nlm.nih.gov/pubmed/37554454 http://dx.doi.org/10.1016/j.isci.2023.107336 |
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