Severity of SARS-CoV-2 Omicron XBB subvariants in Singapore

Several XBB subvariants such as XBB.1.5, XBB.1.9, XBB.1.16 and XBB.2.3 co-circulate in Singapore. Despite the different viral properties of XBB.1.16 as compared to other XBB subvariants, comparison on their severity is limited. In this study, we investigate the outcomes of hospitalisation and severe...

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Detalles Bibliográficos
Autores principales: Pung, Rachael, Kong, Xin Peng, Cui, Lin, Chae, Sae-Rom, Chen, Mark I-Cheng, Lee, Vernon J., Ho, Zheng Jie Marc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Correspondence
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10405309/
https://www.ncbi.nlm.nih.gov/pubmed/37554470
http://dx.doi.org/10.1016/j.lanwpc.2023.100849
Descripción
Sumario:Several XBB subvariants such as XBB.1.5, XBB.1.9, XBB.1.16 and XBB.2.3 co-circulate in Singapore. Despite the different viral properties of XBB.1.16 as compared to other XBB subvariants, comparison on their severity is limited. In this study, we investigate the outcomes of hospitalisation and severe COVID-19 infection in individuals infected with different XBB subvariants, adjusted for potential confounders such as age and vaccination history. Overall, our preliminary analysis showed that the risk of severe outcomes when infected with XBB.1.16 is higher than that of XBB.1.5 or XBB.1.9 but there is no difference in the risk of hospitalisation across different XBB subvariants.

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