Severity of SARS-CoV-2 Omicron XBB subvariants in Singapore

Several XBB subvariants such as XBB.1.5, XBB.1.9, XBB.1.16 and XBB.2.3 co-circulate in Singapore. Despite the different viral properties of XBB.1.16 as compared to other XBB subvariants, comparison on their severity is limited. In this study, we investigate the outcomes of hospitalisation and severe...

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Autores principales: Pung, Rachael, Kong, Xin Peng, Cui, Lin, Chae, Sae-Rom, Chen, Mark I-Cheng, Lee, Vernon J., Ho, Zheng Jie Marc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Correspondence
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10405309/
https://www.ncbi.nlm.nih.gov/pubmed/37554470
http://dx.doi.org/10.1016/j.lanwpc.2023.100849
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author Pung, Rachael
Kong, Xin Peng
Cui, Lin
Chae, Sae-Rom
Chen, Mark I-Cheng
Lee, Vernon J.
Ho, Zheng Jie Marc
author_facet Pung, Rachael
Kong, Xin Peng
Cui, Lin
Chae, Sae-Rom
Chen, Mark I-Cheng
Lee, Vernon J.
Ho, Zheng Jie Marc
author_sort Pung, Rachael
collection PubMed
description Several XBB subvariants such as XBB.1.5, XBB.1.9, XBB.1.16 and XBB.2.3 co-circulate in Singapore. Despite the different viral properties of XBB.1.16 as compared to other XBB subvariants, comparison on their severity is limited. In this study, we investigate the outcomes of hospitalisation and severe COVID-19 infection in individuals infected with different XBB subvariants, adjusted for potential confounders such as age and vaccination history. Overall, our preliminary analysis showed that the risk of severe outcomes when infected with XBB.1.16 is higher than that of XBB.1.5 or XBB.1.9 but there is no difference in the risk of hospitalisation across different XBB subvariants.
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spelling pubmed-104053092023-08-08 Severity of SARS-CoV-2 Omicron XBB subvariants in Singapore Pung, Rachael Kong, Xin Peng Cui, Lin Chae, Sae-Rom Chen, Mark I-Cheng Lee, Vernon J. Ho, Zheng Jie Marc Lancet Reg Health West Pac Correspondence Several XBB subvariants such as XBB.1.5, XBB.1.9, XBB.1.16 and XBB.2.3 co-circulate in Singapore. Despite the different viral properties of XBB.1.16 as compared to other XBB subvariants, comparison on their severity is limited. In this study, we investigate the outcomes of hospitalisation and severe COVID-19 infection in individuals infected with different XBB subvariants, adjusted for potential confounders such as age and vaccination history. Overall, our preliminary analysis showed that the risk of severe outcomes when infected with XBB.1.16 is higher than that of XBB.1.5 or XBB.1.9 but there is no difference in the risk of hospitalisation across different XBB subvariants. Elsevier 2023-07-25 /pmc/articles/PMC10405309/ /pubmed/37554470 http://dx.doi.org/10.1016/j.lanwpc.2023.100849 Text en © 2023 The Author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Correspondence
Pung, Rachael
Kong, Xin Peng
Cui, Lin
Chae, Sae-Rom
Chen, Mark I-Cheng
Lee, Vernon J.
Ho, Zheng Jie Marc
Severity of SARS-CoV-2 Omicron XBB subvariants in Singapore
title Severity of SARS-CoV-2 Omicron XBB subvariants in Singapore
title_full Severity of SARS-CoV-2 Omicron XBB subvariants in Singapore
title_fullStr Severity of SARS-CoV-2 Omicron XBB subvariants in Singapore
title_full_unstemmed Severity of SARS-CoV-2 Omicron XBB subvariants in Singapore
title_short Severity of SARS-CoV-2 Omicron XBB subvariants in Singapore
title_sort severity of sars-cov-2 omicron xbb subvariants in singapore
topic Correspondence
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10405309/
https://www.ncbi.nlm.nih.gov/pubmed/37554470
http://dx.doi.org/10.1016/j.lanwpc.2023.100849
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