Correlation investigation between a single nucleotide polymorphism in ADAMTS14 (rs4747096) and osteoarthritis: a meta-analysis

BACKGROUND: Current evidence of the association between a single nucleotide polymorphism (SNP) in ADAMTS14 (rs4747096) and osteoarthritis (OA) is controversial. This study aimed to determine whether the ADAMTS14 SNP is closely related to OA risk. METHODS: An electronic search of for the association between the rs4747096 polymorphisms and OA was performed using four online databases (updated on September 10, 2022). The association between susceptibility to OA and rs4747096 polymorphism was evaluated in four genetic models: the allele (mutation [A] vs. wild type [G]), additive (AA vs. GG and AG vs. GG), recessive (AA vs. AG + GG), and dominant (AA + AG vs. GG). This meta-analysis was performed in the R software, and effects were assessed using odds ratios (ORs) and 95% confidence intervals (CI). RESULTS: Four studies (707 cases in the case group and 859 cases in the control group) were included. The results of the meta-analysis showed that, except in the recessive genetic model, there was a significant correlation between OA risk and the rs4747096 polymorphism using the allele (OR [95% CI] = 1.48 [1.26–1.73], P < 0.001), additive (AG vs. GG, OR [95% CI] = 2.56 [1.79–3.65], P < 0.001; AA vs. GG, OR [95% CI] = 2.81 [1.98–3.98], P < 0.001), and dominant (OR [95% CI)] = 1.72 [1.34–2.2], P < 0.001) genetic models. CONCLUSIONS: The ADAMTS14 rs4747096 polymorphism is associated with susceptibility to OA.