Alkylation of nucleobases by 2-chloro-N,N-diethylethanamine hydrochloride (CDEAH) sensitizes PARP1-deficient tumors

Targeting BRCA1- and BRCA2-deficient tumors through synthetic lethality using poly(ADP-ribose) polymerase inhibitors (PARPi) has emerged as a successful strategy for cancer therapy. PARPi monotherapy has shown excellent efficacy and safety profiles in clinical practice but is limited by the need for...

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Detalles Bibliográficos
Autores principales: Wie, Minwoo, Khim, Keon Woo, Groehler IV, Arnold S, Heo, Soomin, Woo, Junhyeok, Son, Kook, Lee, Eun A, Ra, Jae Sun, Hong, Sung You, Schärer, Orlando D, Choi, Jang Hyun, Myung, Kyungjae
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
DNA Damage Sensing and Repair
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10405566/
https://www.ncbi.nlm.nih.gov/pubmed/37554969
http://dx.doi.org/10.1093/narcan/zcad042

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10405566/
https://www.ncbi.nlm.nih.gov/pubmed/37554969
http://dx.doi.org/10.1093/narcan/zcad042

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