Cargando…

Natriuretic peptide biomarkers in the imminent development of preeclampsia

Preeclampsia is the most common cause of morbidity and mortality in pregnancy, the incidence being significantly higher in low-income countries with reduced access to health care. Women with preeclampsia are at a higher risk of developing cardiovascular disease with a poorer long-term outcome. Early...

Descripción completa

Detalles Bibliográficos
Autores principales: Marek-Iannucci, Stefanie, Oliveros, Estefania, Brailovsky, Yevgeniy, Pirlamarla, Preethi, Roman, Amanda, Rajapreyar, Indranee N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10405731/
https://www.ncbi.nlm.nih.gov/pubmed/37554369
http://dx.doi.org/10.3389/fcvm.2023.1203516
_version_ 1785085599412125696
author Marek-Iannucci, Stefanie
Oliveros, Estefania
Brailovsky, Yevgeniy
Pirlamarla, Preethi
Roman, Amanda
Rajapreyar, Indranee N.
author_facet Marek-Iannucci, Stefanie
Oliveros, Estefania
Brailovsky, Yevgeniy
Pirlamarla, Preethi
Roman, Amanda
Rajapreyar, Indranee N.
author_sort Marek-Iannucci, Stefanie
collection PubMed
description Preeclampsia is the most common cause of morbidity and mortality in pregnancy, the incidence being significantly higher in low-income countries with reduced access to health care. Women with preeclampsia are at a higher risk of developing cardiovascular disease with a poorer long-term outcome. Early recognition and treatment are key to improving short- and long-term outcomes. Approximately 3%–5% of pregnant women will develop preeclampsia, with potentially fatal outcomes. Despite ongoing research, the exact pathophysiologic mechanism behind its development remains unclear. In this brief report, we describe the potential role of natriuretic peptides as biomarkers in the imminent development of preeclampsia. In a retrospective manner, we analyzed changes in the left ventricular ejection fraction and left atrial volume and increases in natriuretic peptide in correlation with the development of preeclampsia. We found that three out of four patients developed a significant increase in natriuretic peptide, which correlated with the development of preeclampsia and/or peripartum cardiomyopathy. Significant increases in natriuretic peptides around the time of delivery might be a marker for the imminent development of preeclampsia. Close monitoring of natriuretic peptide levels in the peripartum period could give important insight into the imminent development of preeclampsia in high-risk patients. Close follow-up in specialized cardio-obstetric clinics is highly recommended.
format Online
Article
Text
id pubmed-10405731
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-104057312023-08-08 Natriuretic peptide biomarkers in the imminent development of preeclampsia Marek-Iannucci, Stefanie Oliveros, Estefania Brailovsky, Yevgeniy Pirlamarla, Preethi Roman, Amanda Rajapreyar, Indranee N. Front Cardiovasc Med Cardiovascular Medicine Preeclampsia is the most common cause of morbidity and mortality in pregnancy, the incidence being significantly higher in low-income countries with reduced access to health care. Women with preeclampsia are at a higher risk of developing cardiovascular disease with a poorer long-term outcome. Early recognition and treatment are key to improving short- and long-term outcomes. Approximately 3%–5% of pregnant women will develop preeclampsia, with potentially fatal outcomes. Despite ongoing research, the exact pathophysiologic mechanism behind its development remains unclear. In this brief report, we describe the potential role of natriuretic peptides as biomarkers in the imminent development of preeclampsia. In a retrospective manner, we analyzed changes in the left ventricular ejection fraction and left atrial volume and increases in natriuretic peptide in correlation with the development of preeclampsia. We found that three out of four patients developed a significant increase in natriuretic peptide, which correlated with the development of preeclampsia and/or peripartum cardiomyopathy. Significant increases in natriuretic peptides around the time of delivery might be a marker for the imminent development of preeclampsia. Close monitoring of natriuretic peptide levels in the peripartum period could give important insight into the imminent development of preeclampsia in high-risk patients. Close follow-up in specialized cardio-obstetric clinics is highly recommended. Frontiers Media S.A. 2023-07-24 /pmc/articles/PMC10405731/ /pubmed/37554369 http://dx.doi.org/10.3389/fcvm.2023.1203516 Text en © 2023 Marek-Iannucci, Oliveros, Brailovsky, Pirlamarla, Roman and Rajapreyar. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cardiovascular Medicine
Marek-Iannucci, Stefanie
Oliveros, Estefania
Brailovsky, Yevgeniy
Pirlamarla, Preethi
Roman, Amanda
Rajapreyar, Indranee N.
Natriuretic peptide biomarkers in the imminent development of preeclampsia
title Natriuretic peptide biomarkers in the imminent development of preeclampsia
title_full Natriuretic peptide biomarkers in the imminent development of preeclampsia
title_fullStr Natriuretic peptide biomarkers in the imminent development of preeclampsia
title_full_unstemmed Natriuretic peptide biomarkers in the imminent development of preeclampsia
title_short Natriuretic peptide biomarkers in the imminent development of preeclampsia
title_sort natriuretic peptide biomarkers in the imminent development of preeclampsia
topic Cardiovascular Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10405731/
https://www.ncbi.nlm.nih.gov/pubmed/37554369
http://dx.doi.org/10.3389/fcvm.2023.1203516
work_keys_str_mv AT marekiannuccistefanie natriureticpeptidebiomarkersintheimminentdevelopmentofpreeclampsia
AT oliverosestefania natriureticpeptidebiomarkersintheimminentdevelopmentofpreeclampsia
AT brailovskyyevgeniy natriureticpeptidebiomarkersintheimminentdevelopmentofpreeclampsia
AT pirlamarlapreethi natriureticpeptidebiomarkersintheimminentdevelopmentofpreeclampsia
AT romanamanda natriureticpeptidebiomarkersintheimminentdevelopmentofpreeclampsia
AT rajapreyarindraneen natriureticpeptidebiomarkersintheimminentdevelopmentofpreeclampsia