Inhibition by components of Glycyrrhiza uralensis of 3CLpro and HCoV-OC43 proliferation

Coronavirus disease 2019 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). 3CLpro is a key enzyme in coronavirus proliferation and a treatment target for COVID-19. In vitro and in silico, compounds 1–3 from Glycyrrhiza uralensis had inhibitor...

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Autores principales: Kim, Jang Hoon, Park, Yea-In, Hur, Mok, Park, Woo Tae, Moon, Youn-Ho, Huh, Yun-Chan, Kim, Tae IL, Kang, Min Hye, Kang, Jong Seong, Cho, Chong Woon, Park, Junsoo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10405751/
https://www.ncbi.nlm.nih.gov/pubmed/37537881
http://dx.doi.org/10.1080/14756366.2023.2242704
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author Kim, Jang Hoon
Park, Yea-In
Hur, Mok
Park, Woo Tae
Moon, Youn-Ho
Huh, Yun-Chan
Kim, Tae IL
Kang, Min Hye
Kang, Jong Seong
Cho, Chong Woon
Park, Junsoo
author_facet Kim, Jang Hoon
Park, Yea-In
Hur, Mok
Park, Woo Tae
Moon, Youn-Ho
Huh, Yun-Chan
Kim, Tae IL
Kang, Min Hye
Kang, Jong Seong
Cho, Chong Woon
Park, Junsoo
author_sort Kim, Jang Hoon
collection PubMed
description Coronavirus disease 2019 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). 3CLpro is a key enzyme in coronavirus proliferation and a treatment target for COVID-19. In vitro and in silico, compounds 1–3 from Glycyrrhiza uralensis had inhibitory activity and binding affinity for 3CLpro. These compounds decreased HCoV-OC43 cytotoxicity in RD cells. Moreover, they inhibited viral growth by reducing the amounts of the necessary proteins (M, N, and RDRP). Therefore, compounds 1–3 are inhibitors of 3CLpro and HCoV-OC43 proliferation.
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spelling pubmed-104057512023-08-08 Inhibition by components of Glycyrrhiza uralensis of 3CLpro and HCoV-OC43 proliferation Kim, Jang Hoon Park, Yea-In Hur, Mok Park, Woo Tae Moon, Youn-Ho Huh, Yun-Chan Kim, Tae IL Kang, Min Hye Kang, Jong Seong Cho, Chong Woon Park, Junsoo J Enzyme Inhib Med Chem Research Article Coronavirus disease 2019 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). 3CLpro is a key enzyme in coronavirus proliferation and a treatment target for COVID-19. In vitro and in silico, compounds 1–3 from Glycyrrhiza uralensis had inhibitory activity and binding affinity for 3CLpro. These compounds decreased HCoV-OC43 cytotoxicity in RD cells. Moreover, they inhibited viral growth by reducing the amounts of the necessary proteins (M, N, and RDRP). Therefore, compounds 1–3 are inhibitors of 3CLpro and HCoV-OC43 proliferation. Taylor & Francis 2023-08-03 /pmc/articles/PMC10405751/ /pubmed/37537881 http://dx.doi.org/10.1080/14756366.2023.2242704 Text en © 2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.
spellingShingle Research Article
Kim, Jang Hoon
Park, Yea-In
Hur, Mok
Park, Woo Tae
Moon, Youn-Ho
Huh, Yun-Chan
Kim, Tae IL
Kang, Min Hye
Kang, Jong Seong
Cho, Chong Woon
Park, Junsoo
Inhibition by components of Glycyrrhiza uralensis of 3CLpro and HCoV-OC43 proliferation
title Inhibition by components of Glycyrrhiza uralensis of 3CLpro and HCoV-OC43 proliferation
title_full Inhibition by components of Glycyrrhiza uralensis of 3CLpro and HCoV-OC43 proliferation
title_fullStr Inhibition by components of Glycyrrhiza uralensis of 3CLpro and HCoV-OC43 proliferation
title_full_unstemmed Inhibition by components of Glycyrrhiza uralensis of 3CLpro and HCoV-OC43 proliferation
title_short Inhibition by components of Glycyrrhiza uralensis of 3CLpro and HCoV-OC43 proliferation
title_sort inhibition by components of glycyrrhiza uralensis of 3clpro and hcov-oc43 proliferation
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10405751/
https://www.ncbi.nlm.nih.gov/pubmed/37537881
http://dx.doi.org/10.1080/14756366.2023.2242704
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