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Three specific gut bacteria in the occurrence and development of colorectal cancer: a concerted effort

Colorectal cancer (CRC), which develops from the gradual evolution of tubular adenomas and serrated polyps in the colon and rectum, has a poor prognosis and a high mortality rate. In addition to genetics, lifestyle, and chronic diseases, intestinal integrity and microbiota (which facilitate digestio...

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Autores principales: Gong, Dengmei, Adomako-Bonsu, Amma G, Wang, Maijian, Li, Jida
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PeerJ Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10405800/
https://www.ncbi.nlm.nih.gov/pubmed/37554340
http://dx.doi.org/10.7717/peerj.15777
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author Gong, Dengmei
Adomako-Bonsu, Amma G
Wang, Maijian
Li, Jida
author_facet Gong, Dengmei
Adomako-Bonsu, Amma G
Wang, Maijian
Li, Jida
author_sort Gong, Dengmei
collection PubMed
description Colorectal cancer (CRC), which develops from the gradual evolution of tubular adenomas and serrated polyps in the colon and rectum, has a poor prognosis and a high mortality rate. In addition to genetics, lifestyle, and chronic diseases, intestinal integrity and microbiota (which facilitate digestion, metabolism, and immune regulation) could promote CRC development. For example, enterotoxigenic Bacteroides fragilis, genotoxic Escherichia coli (pks+ E. coli), and Fusobacterium nucleatum, members of the intestinal microbiota, are highly correlated in CRC. This review describes the roles and mechanisms of these three bacteria in CRC development. Their interaction during CRC initiation and progression has also been proposed. Our view is that in the precancerous stage of colorectal cancer, ETBF causes inflammation, leading to potential changes in intestinal ecology that may provide the basic conditions for pks+ E. coli colonization and induction of oncogenic mutations, when cancerous intestinal epithelial cells can further recruit F. nucleatum to colonise the lesion site and F. nucleatum may contribute to CRC advancement by primarily the development of cancer cells, stemization, and proliferation, which could create new and tailored preventive, screening and therapeutic interventions. However, there is the most dominant microbiota in each stage of CRC development, not neglecting the possibility that two or even all three bacteria could be engaged at any stage of the disease. The relationship between the associated gut microbiota and CRC development may provide important information for therapeutic strategies to assess the potential use of the associated gut microbiota in CRC studies, antibiotic therapy, and prevention strategies.
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spelling pubmed-104058002023-08-08 Three specific gut bacteria in the occurrence and development of colorectal cancer: a concerted effort Gong, Dengmei Adomako-Bonsu, Amma G Wang, Maijian Li, Jida PeerJ Microbiology Colorectal cancer (CRC), which develops from the gradual evolution of tubular adenomas and serrated polyps in the colon and rectum, has a poor prognosis and a high mortality rate. In addition to genetics, lifestyle, and chronic diseases, intestinal integrity and microbiota (which facilitate digestion, metabolism, and immune regulation) could promote CRC development. For example, enterotoxigenic Bacteroides fragilis, genotoxic Escherichia coli (pks+ E. coli), and Fusobacterium nucleatum, members of the intestinal microbiota, are highly correlated in CRC. This review describes the roles and mechanisms of these three bacteria in CRC development. Their interaction during CRC initiation and progression has also been proposed. Our view is that in the precancerous stage of colorectal cancer, ETBF causes inflammation, leading to potential changes in intestinal ecology that may provide the basic conditions for pks+ E. coli colonization and induction of oncogenic mutations, when cancerous intestinal epithelial cells can further recruit F. nucleatum to colonise the lesion site and F. nucleatum may contribute to CRC advancement by primarily the development of cancer cells, stemization, and proliferation, which could create new and tailored preventive, screening and therapeutic interventions. However, there is the most dominant microbiota in each stage of CRC development, not neglecting the possibility that two or even all three bacteria could be engaged at any stage of the disease. The relationship between the associated gut microbiota and CRC development may provide important information for therapeutic strategies to assess the potential use of the associated gut microbiota in CRC studies, antibiotic therapy, and prevention strategies. PeerJ Inc. 2023-08-04 /pmc/articles/PMC10405800/ /pubmed/37554340 http://dx.doi.org/10.7717/peerj.15777 Text en © 2023 Gong et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ) and either DOI or URL of the article must be cited.
spellingShingle Microbiology
Gong, Dengmei
Adomako-Bonsu, Amma G
Wang, Maijian
Li, Jida
Three specific gut bacteria in the occurrence and development of colorectal cancer: a concerted effort
title Three specific gut bacteria in the occurrence and development of colorectal cancer: a concerted effort
title_full Three specific gut bacteria in the occurrence and development of colorectal cancer: a concerted effort
title_fullStr Three specific gut bacteria in the occurrence and development of colorectal cancer: a concerted effort
title_full_unstemmed Three specific gut bacteria in the occurrence and development of colorectal cancer: a concerted effort
title_short Three specific gut bacteria in the occurrence and development of colorectal cancer: a concerted effort
title_sort three specific gut bacteria in the occurrence and development of colorectal cancer: a concerted effort
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10405800/
https://www.ncbi.nlm.nih.gov/pubmed/37554340
http://dx.doi.org/10.7717/peerj.15777
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