Preconditioned extracellular vesicles from hypoxic microglia reduce poststroke AQP4 depolarization, disturbed cerebrospinal fluid flow, astrogliosis, and neuroinflammation

Background: Stroke stimulates reactive astrogliosis, aquaporin 4 (AQP4) depolarization and neuroinflammation. Preconditioned extracellular vesicles (EVs) from microglia exposed to hypoxia, in turn, reduce poststroke brain injury. Nevertheless, the underlying mechanisms of such effects are elusive, e...

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Detalles Bibliográficos
Autores principales: Xin, Wenqiang, Pan, Yongli, Wei, Wei, Tatenhorst, Lars, Graf, Irina, Popa-Wagner, Aurel, Gerner, Stefan T, Huber, Sabine, Kilic, Ertugrul, Hermann, Dirk M, Bähr, Mathias, Huttner, Hagen B, Doeppner, Thorsten R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2023
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10405850/
https://www.ncbi.nlm.nih.gov/pubmed/37554272
http://dx.doi.org/10.7150/thno.84059

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