Protein phosphatase 2A-B55β mediated mitochondrial p-GPX4 dephosphorylation promoted sorafenib-induced ferroptosis in hepatocellular carcinoma via regulating p53 retrograde signaling

Rationale: As a key endogenous negative regulator of ferroptosis, glutathione peroxidase 4 (GPX4) can regulate its antioxidant function through multiple post-translational modification pathways. However, the effects of the phosphorylation/dephosphorylation status of GPX4 on the regulation of inducib...

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Detalles Bibliográficos
Autores principales: Qian, Bo, Che, Lin, Du, Ze-Bang, Guo, Ni-Jun, Wu, Xin-Mou, Yang, Lei, Zheng, Zhao-Xuan, Gao, Yun-Lu, Wang, Ming-Zhu, Chen, Xiao-Xuan, Xu, Ling, Zhou, Zi-Jian, Lin, Yu-Chun, Lin, Zhong-Ning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2023
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10405852/
https://www.ncbi.nlm.nih.gov/pubmed/37554285
http://dx.doi.org/10.7150/thno.82132

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