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New strategies of neurodegenerative disease treatment with extracellular vesicles (EVs) derived from mesenchymal stem cells (MSCs)

Neurodegenerative diseases are characterized by the progressive loss of neurons and intricate interactions between different cell types within the affected regions. Reliable biomarkers that can accurately reflect disease activity, diagnose, and monitor the progression of neurodegenerative diseases a...

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Autores principales: Palanisamy, Chella Perumal, Pei, JinJin, Alugoju, Phaniendra, Anthikapalli, Naga Venkata Anusha, Jayaraman, Selvaraj, Veeraraghavan, Vishnu Priya, Gopathy, Sridevi, Roy, Jeane Rebecca, Janaki, Coimbatore Sadagopan, Thalamati, Dwarakesh, Mironescu, Monica, Luo, Qiang, Miao, Yu, Chai, Yuan, Long, Qianfa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10405853/
https://www.ncbi.nlm.nih.gov/pubmed/37554286
http://dx.doi.org/10.7150/thno.83066
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author Palanisamy, Chella Perumal
Pei, JinJin
Alugoju, Phaniendra
Anthikapalli, Naga Venkata Anusha
Jayaraman, Selvaraj
Veeraraghavan, Vishnu Priya
Gopathy, Sridevi
Roy, Jeane Rebecca
Janaki, Coimbatore Sadagopan
Thalamati, Dwarakesh
Mironescu, Monica
Luo, Qiang
Miao, Yu
Chai, Yuan
Long, Qianfa
author_facet Palanisamy, Chella Perumal
Pei, JinJin
Alugoju, Phaniendra
Anthikapalli, Naga Venkata Anusha
Jayaraman, Selvaraj
Veeraraghavan, Vishnu Priya
Gopathy, Sridevi
Roy, Jeane Rebecca
Janaki, Coimbatore Sadagopan
Thalamati, Dwarakesh
Mironescu, Monica
Luo, Qiang
Miao, Yu
Chai, Yuan
Long, Qianfa
author_sort Palanisamy, Chella Perumal
collection PubMed
description Neurodegenerative diseases are characterized by the progressive loss of neurons and intricate interactions between different cell types within the affected regions. Reliable biomarkers that can accurately reflect disease activity, diagnose, and monitor the progression of neurodegenerative diseases are crucial for the development of effective therapies. However, identifying suitable biomarkers has been challenging due to the heterogeneous nature of these diseases, affecting specific subsets of neurons in different brain regions. One promising approach for promoting brain regeneration and recovery involves the transplantation of mesenchymal stem cells (MSCs). MSCs have demonstrated the ability to modulate the immune system, promote neurite outgrowth, stimulate angiogenesis, and repair damaged tissues, partially through the release of their extracellular vesicles (EVs). MSC-derived EVs retain some of the therapeutic characteristics of their parent MSCs, including their ability to regulate neurite outgrowth, promote angiogenesis, and facilitate tissue repair. This review aims to explore the potential of MSC-derived EVs as an emerging therapeutic strategy for neurodegenerative diseases, highlighting their role in modulating disease progression and promoting neuronal recovery. By elucidating the mechanisms by which MSC-derived EVs exert their therapeutic effects, we can advance our understanding and leverage their potential for the development of novel treatment approaches in the field of neurodegenerative diseases.
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spelling pubmed-104058532023-08-08 New strategies of neurodegenerative disease treatment with extracellular vesicles (EVs) derived from mesenchymal stem cells (MSCs) Palanisamy, Chella Perumal Pei, JinJin Alugoju, Phaniendra Anthikapalli, Naga Venkata Anusha Jayaraman, Selvaraj Veeraraghavan, Vishnu Priya Gopathy, Sridevi Roy, Jeane Rebecca Janaki, Coimbatore Sadagopan Thalamati, Dwarakesh Mironescu, Monica Luo, Qiang Miao, Yu Chai, Yuan Long, Qianfa Theranostics Review Neurodegenerative diseases are characterized by the progressive loss of neurons and intricate interactions between different cell types within the affected regions. Reliable biomarkers that can accurately reflect disease activity, diagnose, and monitor the progression of neurodegenerative diseases are crucial for the development of effective therapies. However, identifying suitable biomarkers has been challenging due to the heterogeneous nature of these diseases, affecting specific subsets of neurons in different brain regions. One promising approach for promoting brain regeneration and recovery involves the transplantation of mesenchymal stem cells (MSCs). MSCs have demonstrated the ability to modulate the immune system, promote neurite outgrowth, stimulate angiogenesis, and repair damaged tissues, partially through the release of their extracellular vesicles (EVs). MSC-derived EVs retain some of the therapeutic characteristics of their parent MSCs, including their ability to regulate neurite outgrowth, promote angiogenesis, and facilitate tissue repair. This review aims to explore the potential of MSC-derived EVs as an emerging therapeutic strategy for neurodegenerative diseases, highlighting their role in modulating disease progression and promoting neuronal recovery. By elucidating the mechanisms by which MSC-derived EVs exert their therapeutic effects, we can advance our understanding and leverage their potential for the development of novel treatment approaches in the field of neurodegenerative diseases. Ivyspring International Publisher 2023-07-16 /pmc/articles/PMC10405853/ /pubmed/37554286 http://dx.doi.org/10.7150/thno.83066 Text en © The author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Review
Palanisamy, Chella Perumal
Pei, JinJin
Alugoju, Phaniendra
Anthikapalli, Naga Venkata Anusha
Jayaraman, Selvaraj
Veeraraghavan, Vishnu Priya
Gopathy, Sridevi
Roy, Jeane Rebecca
Janaki, Coimbatore Sadagopan
Thalamati, Dwarakesh
Mironescu, Monica
Luo, Qiang
Miao, Yu
Chai, Yuan
Long, Qianfa
New strategies of neurodegenerative disease treatment with extracellular vesicles (EVs) derived from mesenchymal stem cells (MSCs)
title New strategies of neurodegenerative disease treatment with extracellular vesicles (EVs) derived from mesenchymal stem cells (MSCs)
title_full New strategies of neurodegenerative disease treatment with extracellular vesicles (EVs) derived from mesenchymal stem cells (MSCs)
title_fullStr New strategies of neurodegenerative disease treatment with extracellular vesicles (EVs) derived from mesenchymal stem cells (MSCs)
title_full_unstemmed New strategies of neurodegenerative disease treatment with extracellular vesicles (EVs) derived from mesenchymal stem cells (MSCs)
title_short New strategies of neurodegenerative disease treatment with extracellular vesicles (EVs) derived from mesenchymal stem cells (MSCs)
title_sort new strategies of neurodegenerative disease treatment with extracellular vesicles (evs) derived from mesenchymal stem cells (mscs)
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10405853/
https://www.ncbi.nlm.nih.gov/pubmed/37554286
http://dx.doi.org/10.7150/thno.83066
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