iNOS aggravates pressure overload-induced cardiac dysfunction via activation of the cytosolic-mtDNA-mediated cGAS-STING pathway

Background: Sterile inflammation contributes to the pathogenesis of cardiac dysfunction caused by various conditions including pressure overload in hypertension. Mitochondrial DNA (mtDNA) released from damaged mitochondria has been implicated in cardiac inflammation. However, the upstream mechanisms...

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Detalles Bibliográficos
Autores principales: Guo, Yongzheng, You, Yuehua, Shang, Fei-Fei, Wang, Xiaowen, Huang, Bi, Zhao, Boying, Lv, Dingyi, Yang, Shenglan, Xie, Ming, Kong, Lingwen, Du, Dingyuan, Luo, Suxin, Tian, Xin, Xia, Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2023
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10405855/
https://www.ncbi.nlm.nih.gov/pubmed/37554263
http://dx.doi.org/10.7150/thno.84049

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