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Early changes of ganglion cell-inner plexiform layer thickness and macular microvasculature in Posner-Schlossman syndrome: a binocular control study by OCTA
To evaluate the early changes in ganglion cell-inner plexiform layer thickness and macular microvasculature in Posner-Schlossman syndrome (PSS) with a binocular control study involving optical coherence tomography angiography (OCTA). Twenty-six patients with unilateral PSS were included in this cros...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10405927/ https://www.ncbi.nlm.nih.gov/pubmed/37554506 http://dx.doi.org/10.3389/fmed.2023.1169504 |
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author | Hu, Zhiyi Zhu, Liwei Xu, Junli Wei, Jiamin Wu, Shuangqing Dai, Qi Xu, Qibin |
author_facet | Hu, Zhiyi Zhu, Liwei Xu, Junli Wei, Jiamin Wu, Shuangqing Dai, Qi Xu, Qibin |
author_sort | Hu, Zhiyi |
collection | PubMed |
description | To evaluate the early changes in ganglion cell-inner plexiform layer thickness and macular microvasculature in Posner-Schlossman syndrome (PSS) with a binocular control study involving optical coherence tomography angiography (OCTA). Twenty-six patients with unilateral PSS were included in this cross-sectional study. All subjects underwent a thorough ocular examination. Macular ganglion cell-inner plexiform layer (mGCIPL) and superficial macular microvasculature measurements, including vessel density (VD), perfusion density (PD) and the foveal avascular zone (FAZ), were recorded. In PSS-affected eyes, the mGCIPL thickness was significantly lower in all quadrants than in the contralateral eyes (all p < 0.05). Significant macular microvascular damage was found in the PSS-affected eyes, including whole-image VD (wiVD), wiPD, perifoveal VD (periVD) and periPD (all p < 0.05); but there was no obvious difference in parafoveal VD (paraVD), paraPD and FAZ parameters (all p > 0.05). In addition, a decreased wiVD and wiPD were significantly correlated with a smaller mGCIPL thickness and a decreased MD (all p < 0.05). These parameters may contribute to the early detection of glaucomatous damage and timely supervision of disease progression in PSS. |
format | Online Article Text |
id | pubmed-10405927 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-104059272023-08-08 Early changes of ganglion cell-inner plexiform layer thickness and macular microvasculature in Posner-Schlossman syndrome: a binocular control study by OCTA Hu, Zhiyi Zhu, Liwei Xu, Junli Wei, Jiamin Wu, Shuangqing Dai, Qi Xu, Qibin Front Med (Lausanne) Medicine To evaluate the early changes in ganglion cell-inner plexiform layer thickness and macular microvasculature in Posner-Schlossman syndrome (PSS) with a binocular control study involving optical coherence tomography angiography (OCTA). Twenty-six patients with unilateral PSS were included in this cross-sectional study. All subjects underwent a thorough ocular examination. Macular ganglion cell-inner plexiform layer (mGCIPL) and superficial macular microvasculature measurements, including vessel density (VD), perfusion density (PD) and the foveal avascular zone (FAZ), were recorded. In PSS-affected eyes, the mGCIPL thickness was significantly lower in all quadrants than in the contralateral eyes (all p < 0.05). Significant macular microvascular damage was found in the PSS-affected eyes, including whole-image VD (wiVD), wiPD, perifoveal VD (periVD) and periPD (all p < 0.05); but there was no obvious difference in parafoveal VD (paraVD), paraPD and FAZ parameters (all p > 0.05). In addition, a decreased wiVD and wiPD were significantly correlated with a smaller mGCIPL thickness and a decreased MD (all p < 0.05). These parameters may contribute to the early detection of glaucomatous damage and timely supervision of disease progression in PSS. Frontiers Media S.A. 2023-07-24 /pmc/articles/PMC10405927/ /pubmed/37554506 http://dx.doi.org/10.3389/fmed.2023.1169504 Text en Copyright © 2023 Hu, Zhu, Xu, Wei, Wu, Dai and Xu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Medicine Hu, Zhiyi Zhu, Liwei Xu, Junli Wei, Jiamin Wu, Shuangqing Dai, Qi Xu, Qibin Early changes of ganglion cell-inner plexiform layer thickness and macular microvasculature in Posner-Schlossman syndrome: a binocular control study by OCTA |
title | Early changes of ganglion cell-inner plexiform layer thickness and macular microvasculature in Posner-Schlossman syndrome: a binocular control study by OCTA |
title_full | Early changes of ganglion cell-inner plexiform layer thickness and macular microvasculature in Posner-Schlossman syndrome: a binocular control study by OCTA |
title_fullStr | Early changes of ganglion cell-inner plexiform layer thickness and macular microvasculature in Posner-Schlossman syndrome: a binocular control study by OCTA |
title_full_unstemmed | Early changes of ganglion cell-inner plexiform layer thickness and macular microvasculature in Posner-Schlossman syndrome: a binocular control study by OCTA |
title_short | Early changes of ganglion cell-inner plexiform layer thickness and macular microvasculature in Posner-Schlossman syndrome: a binocular control study by OCTA |
title_sort | early changes of ganglion cell-inner plexiform layer thickness and macular microvasculature in posner-schlossman syndrome: a binocular control study by octa |
topic | Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10405927/ https://www.ncbi.nlm.nih.gov/pubmed/37554506 http://dx.doi.org/10.3389/fmed.2023.1169504 |
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