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3D printing of mechanically tough and self-healing hydrogels with carbon nanotube fillers

Hydrogels have the potential to play a crucial role in bioelectronics, as they share many properties with human tissues. However, to effectively bridge the gap between electronics and biological systems, hydrogels must possess multiple functionalities, including toughness, stretchability, self-heali...

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Autores principales: Kim, Soo A, Lee, Yeontaek, Park, Kijun, Park, Jae, An, Soohwan, Oh, Jinseok, Kang, Minkyong, Lee, Yurim, Jo, Yejin, Cho, Seung-Woo, Seo, Jungmok
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Whioce Publishing Pte. Ltd. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10406165/
https://www.ncbi.nlm.nih.gov/pubmed/37555082
http://dx.doi.org/10.18063/ijb.765
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author Kim, Soo A
Lee, Yeontaek
Park, Kijun
Park, Jae
An, Soohwan
Oh, Jinseok
Kang, Minkyong
Lee, Yurim
Jo, Yejin
Cho, Seung-Woo
Seo, Jungmok
author_facet Kim, Soo A
Lee, Yeontaek
Park, Kijun
Park, Jae
An, Soohwan
Oh, Jinseok
Kang, Minkyong
Lee, Yurim
Jo, Yejin
Cho, Seung-Woo
Seo, Jungmok
author_sort Kim, Soo A
collection PubMed
description Hydrogels have the potential to play a crucial role in bioelectronics, as they share many properties with human tissues. However, to effectively bridge the gap between electronics and biological systems, hydrogels must possess multiple functionalities, including toughness, stretchability, self-healing ability, three-dimensional (3D) printability, and electrical conductivity. Fabricating such tough and self-healing materials has been reported, but it still remains a challenge to fulfill all of those features, and in particular, 3D printing of hydrogel is in the early stage of the research. In this paper, we present a 3D printable, tough, and self-healing multi-functional hydrogel in one platform made from a blend of poly(vinyl alcohol) (PVA), tannic acid (TA), and poly(acrylic acid) (PAA) hydrogel ink (PVA/TA/PAA hydrogel ink). Based on a reversible hydrogen-bond (H-bond)-based double network, the developed 3D printable hydrogel ink showed excellent printability via shear-thinning behavior, allowing high printing resolution (~100 μm) and successful fabrication of 3D-printed structure by layer-by-layer printing. Moreover, the PVA/TA/PAA hydrogel ink exhibited high toughness (tensile loading of up to ~45.6 kPa), stretchability (elongation of approximately 650%), tissue-like Young’s modulus (~15 kPa), and self-healing ability within 5 min. Furthermore, carbon nanotube (CNT) fillers were successfully added to enhance the electrical conductivity of the hydrogel. We confirmed the practicality of the hydrogel inks for bioelectronics by demonstrating biocompatibility, tissue adhesiveness, and strain sensing ability through PVA/TA/PAA/CNT hydrogel ink.
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spelling pubmed-104061652023-08-08 3D printing of mechanically tough and self-healing hydrogels with carbon nanotube fillers Kim, Soo A Lee, Yeontaek Park, Kijun Park, Jae An, Soohwan Oh, Jinseok Kang, Minkyong Lee, Yurim Jo, Yejin Cho, Seung-Woo Seo, Jungmok Int J Bioprint Research Article Hydrogels have the potential to play a crucial role in bioelectronics, as they share many properties with human tissues. However, to effectively bridge the gap between electronics and biological systems, hydrogels must possess multiple functionalities, including toughness, stretchability, self-healing ability, three-dimensional (3D) printability, and electrical conductivity. Fabricating such tough and self-healing materials has been reported, but it still remains a challenge to fulfill all of those features, and in particular, 3D printing of hydrogel is in the early stage of the research. In this paper, we present a 3D printable, tough, and self-healing multi-functional hydrogel in one platform made from a blend of poly(vinyl alcohol) (PVA), tannic acid (TA), and poly(acrylic acid) (PAA) hydrogel ink (PVA/TA/PAA hydrogel ink). Based on a reversible hydrogen-bond (H-bond)-based double network, the developed 3D printable hydrogel ink showed excellent printability via shear-thinning behavior, allowing high printing resolution (~100 μm) and successful fabrication of 3D-printed structure by layer-by-layer printing. Moreover, the PVA/TA/PAA hydrogel ink exhibited high toughness (tensile loading of up to ~45.6 kPa), stretchability (elongation of approximately 650%), tissue-like Young’s modulus (~15 kPa), and self-healing ability within 5 min. Furthermore, carbon nanotube (CNT) fillers were successfully added to enhance the electrical conductivity of the hydrogel. We confirmed the practicality of the hydrogel inks for bioelectronics by demonstrating biocompatibility, tissue adhesiveness, and strain sensing ability through PVA/TA/PAA/CNT hydrogel ink. Whioce Publishing Pte. Ltd. 2023-05-31 /pmc/articles/PMC10406165/ /pubmed/37555082 http://dx.doi.org/10.18063/ijb.765 Text en Copyright:© 2023, Kim SA, Lee Y, Park K, et al https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License, permitting distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Kim, Soo A
Lee, Yeontaek
Park, Kijun
Park, Jae
An, Soohwan
Oh, Jinseok
Kang, Minkyong
Lee, Yurim
Jo, Yejin
Cho, Seung-Woo
Seo, Jungmok
3D printing of mechanically tough and self-healing hydrogels with carbon nanotube fillers
title 3D printing of mechanically tough and self-healing hydrogels with carbon nanotube fillers
title_full 3D printing of mechanically tough and self-healing hydrogels with carbon nanotube fillers
title_fullStr 3D printing of mechanically tough and self-healing hydrogels with carbon nanotube fillers
title_full_unstemmed 3D printing of mechanically tough and self-healing hydrogels with carbon nanotube fillers
title_short 3D printing of mechanically tough and self-healing hydrogels with carbon nanotube fillers
title_sort 3d printing of mechanically tough and self-healing hydrogels with carbon nanotube fillers
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10406165/
https://www.ncbi.nlm.nih.gov/pubmed/37555082
http://dx.doi.org/10.18063/ijb.765
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