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Brain activity studied with magnetic resonance imaging in awake rabbits

We reviewed fMRI experiments from our previous work in conscious rabbits, an experimental preparation that is advantageous for measuring brain activation that is free of anesthetic modulation and which can address questions in a variety of areas in sensory, cognitive, and pharmacological neuroscienc...

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Autores principales: Weiss, Craig, Bertolino, Nicola, Procissi, Daniele, Disterhoft, John F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10406271/
https://www.ncbi.nlm.nih.gov/pubmed/37555136
http://dx.doi.org/10.3389/fnimg.2022.965529
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author Weiss, Craig
Bertolino, Nicola
Procissi, Daniele
Disterhoft, John F.
author_facet Weiss, Craig
Bertolino, Nicola
Procissi, Daniele
Disterhoft, John F.
author_sort Weiss, Craig
collection PubMed
description We reviewed fMRI experiments from our previous work in conscious rabbits, an experimental preparation that is advantageous for measuring brain activation that is free of anesthetic modulation and which can address questions in a variety of areas in sensory, cognitive, and pharmacological neuroscience research. Rabbits do not struggle or move for several hours while sitting with their heads restrained inside the horizontal bore of a magnet. This greatly reduces movement artifacts in magnetic resonance (MR) images in comparison to other experimental animals such as rodents, cats, and monkeys. We have been able to acquire high-resolution anatomic as well as functional images that are free of movement artifacts during several hours of restraint. Results from conscious rabbit fMRI studies with whisker stimulation are provided to illustrate the feasibility of this conscious animal model for functional MRI and the reproducibility of data gained with it.
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spelling pubmed-104062712023-08-08 Brain activity studied with magnetic resonance imaging in awake rabbits Weiss, Craig Bertolino, Nicola Procissi, Daniele Disterhoft, John F. Front Neuroimaging Neuroimaging We reviewed fMRI experiments from our previous work in conscious rabbits, an experimental preparation that is advantageous for measuring brain activation that is free of anesthetic modulation and which can address questions in a variety of areas in sensory, cognitive, and pharmacological neuroscience research. Rabbits do not struggle or move for several hours while sitting with their heads restrained inside the horizontal bore of a magnet. This greatly reduces movement artifacts in magnetic resonance (MR) images in comparison to other experimental animals such as rodents, cats, and monkeys. We have been able to acquire high-resolution anatomic as well as functional images that are free of movement artifacts during several hours of restraint. Results from conscious rabbit fMRI studies with whisker stimulation are provided to illustrate the feasibility of this conscious animal model for functional MRI and the reproducibility of data gained with it. Frontiers Media S.A. 2022-09-07 /pmc/articles/PMC10406271/ /pubmed/37555136 http://dx.doi.org/10.3389/fnimg.2022.965529 Text en Copyright © 2022 Weiss, Bertolino, Procissi and Disterhoft. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroimaging
Weiss, Craig
Bertolino, Nicola
Procissi, Daniele
Disterhoft, John F.
Brain activity studied with magnetic resonance imaging in awake rabbits
title Brain activity studied with magnetic resonance imaging in awake rabbits
title_full Brain activity studied with magnetic resonance imaging in awake rabbits
title_fullStr Brain activity studied with magnetic resonance imaging in awake rabbits
title_full_unstemmed Brain activity studied with magnetic resonance imaging in awake rabbits
title_short Brain activity studied with magnetic resonance imaging in awake rabbits
title_sort brain activity studied with magnetic resonance imaging in awake rabbits
topic Neuroimaging
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10406271/
https://www.ncbi.nlm.nih.gov/pubmed/37555136
http://dx.doi.org/10.3389/fnimg.2022.965529
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