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Dependence of resting-state-based cerebrovascular reactivity (CVR) mapping on spatial resolution

Cerebrovascular reactivity (CVR) is typically assessed with a carbon dioxide (CO(2)) stimulus combined with BOLD fMRI. Recently, resting-state (RS) BOLD fMRI has been shown capable of generating CVR maps, providing a potential for broader CVR applications in neuroimaging studies. However, prior RS-C...

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Autores principales: Liu, Peiying, Hu, Beini, Kartchner, Lincoln, Joshi, Parimal, Xu, Cuimei, Jiang, Dengrong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10406303/
https://www.ncbi.nlm.nih.gov/pubmed/37554643
http://dx.doi.org/10.3389/fnimg.2023.1205459
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author Liu, Peiying
Hu, Beini
Kartchner, Lincoln
Joshi, Parimal
Xu, Cuimei
Jiang, Dengrong
author_facet Liu, Peiying
Hu, Beini
Kartchner, Lincoln
Joshi, Parimal
Xu, Cuimei
Jiang, Dengrong
author_sort Liu, Peiying
collection PubMed
description Cerebrovascular reactivity (CVR) is typically assessed with a carbon dioxide (CO(2)) stimulus combined with BOLD fMRI. Recently, resting-state (RS) BOLD fMRI has been shown capable of generating CVR maps, providing a potential for broader CVR applications in neuroimaging studies. However, prior RS-CVR studies have primarily been performed at a spatial resolution of 3–4 mm voxel sizes. It remains unknown whether RS-CVR can also be obtained at high-resolution without major degradation in image quality. In this study, we investigated RS-CVR mapping based on resting-state BOLD MRI across a range of spatial resolutions in a group of healthy subjects, in an effort to examine the feasibility of RS-CVR measurement at high resolution. Comparing the results of RS-CVR with the maps obtained by the conventional CO2-inhalation method, our results suggested that good CVR map quality can be obtained at a voxel size as small as 2 mm isotropic. Our results also showed that, RS-CVR maps revealed resolution-dependent sensitivity. However, even at a high resolution of 2 mm isotropic voxel size, the voxel-wise sensitivity is still greater than that of typical task-evoked fMRI. Scan duration affected the sensitivity of RS-CVR mapping, but had no significant effect on its accuracy. These findings suggest that RS-CVR mapping can be applied at a similar resolution as state-of-the-art fMRI studies, which will broaden the use of CVR mapping in basic science and clinical applications including retrospective analysis of previously collected fMRI data.
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spelling pubmed-104063032023-08-08 Dependence of resting-state-based cerebrovascular reactivity (CVR) mapping on spatial resolution Liu, Peiying Hu, Beini Kartchner, Lincoln Joshi, Parimal Xu, Cuimei Jiang, Dengrong Front Neuroimaging Neuroimaging Cerebrovascular reactivity (CVR) is typically assessed with a carbon dioxide (CO(2)) stimulus combined with BOLD fMRI. Recently, resting-state (RS) BOLD fMRI has been shown capable of generating CVR maps, providing a potential for broader CVR applications in neuroimaging studies. However, prior RS-CVR studies have primarily been performed at a spatial resolution of 3–4 mm voxel sizes. It remains unknown whether RS-CVR can also be obtained at high-resolution without major degradation in image quality. In this study, we investigated RS-CVR mapping based on resting-state BOLD MRI across a range of spatial resolutions in a group of healthy subjects, in an effort to examine the feasibility of RS-CVR measurement at high resolution. Comparing the results of RS-CVR with the maps obtained by the conventional CO2-inhalation method, our results suggested that good CVR map quality can be obtained at a voxel size as small as 2 mm isotropic. Our results also showed that, RS-CVR maps revealed resolution-dependent sensitivity. However, even at a high resolution of 2 mm isotropic voxel size, the voxel-wise sensitivity is still greater than that of typical task-evoked fMRI. Scan duration affected the sensitivity of RS-CVR mapping, but had no significant effect on its accuracy. These findings suggest that RS-CVR mapping can be applied at a similar resolution as state-of-the-art fMRI studies, which will broaden the use of CVR mapping in basic science and clinical applications including retrospective analysis of previously collected fMRI data. Frontiers Media S.A. 2023-06-26 /pmc/articles/PMC10406303/ /pubmed/37554643 http://dx.doi.org/10.3389/fnimg.2023.1205459 Text en Copyright © 2023 Liu, Hu, Kartchner, Joshi, Xu and Jiang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroimaging
Liu, Peiying
Hu, Beini
Kartchner, Lincoln
Joshi, Parimal
Xu, Cuimei
Jiang, Dengrong
Dependence of resting-state-based cerebrovascular reactivity (CVR) mapping on spatial resolution
title Dependence of resting-state-based cerebrovascular reactivity (CVR) mapping on spatial resolution
title_full Dependence of resting-state-based cerebrovascular reactivity (CVR) mapping on spatial resolution
title_fullStr Dependence of resting-state-based cerebrovascular reactivity (CVR) mapping on spatial resolution
title_full_unstemmed Dependence of resting-state-based cerebrovascular reactivity (CVR) mapping on spatial resolution
title_short Dependence of resting-state-based cerebrovascular reactivity (CVR) mapping on spatial resolution
title_sort dependence of resting-state-based cerebrovascular reactivity (cvr) mapping on spatial resolution
topic Neuroimaging
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10406303/
https://www.ncbi.nlm.nih.gov/pubmed/37554643
http://dx.doi.org/10.3389/fnimg.2023.1205459
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