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Nickle-cobalt alloy nanocrystals inhibit activation of inflammasomes
Activation of inflammasomes—immune system receptor sensor complexes that selectively activate inflammatory responses—has been associated with diverse human diseases, and many nanomedicine studies have reported that structurally and chemically diverse inorganic nanomaterials cause excessive inflammas...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10406336/ https://www.ncbi.nlm.nih.gov/pubmed/37554586 http://dx.doi.org/10.1093/nsr/nwad179 |
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author | Lin, Jun Dong, Liang Liu, Yi-Ming Hu, Yi Jiang, Chen Liu, Ke Liu, Liu Song, Yong-Hong Sun, Mei Xiang, Xing-Cheng Qu, Kun Lu, Yang Wen, Long-Ping Yu, Shu-Hong |
author_facet | Lin, Jun Dong, Liang Liu, Yi-Ming Hu, Yi Jiang, Chen Liu, Ke Liu, Liu Song, Yong-Hong Sun, Mei Xiang, Xing-Cheng Qu, Kun Lu, Yang Wen, Long-Ping Yu, Shu-Hong |
author_sort | Lin, Jun |
collection | PubMed |
description | Activation of inflammasomes—immune system receptor sensor complexes that selectively activate inflammatory responses—has been associated with diverse human diseases, and many nanomedicine studies have reported that structurally and chemically diverse inorganic nanomaterials cause excessive inflammasome activation. Here, in stark contrast to reports of other inorganic nanomaterials, we find that nickel-cobalt alloy magnetic nanocrystals (NiCo NCs) actually inhibit activation of NLRP3, NLRC4 and AIM2 inflammasomes. We show that NiCo NCs disrupt the canonical inflammasome ASC speck formation process by downregulating the lncRNA Neat1, and experimentally confirm that the entry of NiCo NCs into cells is required for the observed inhibition of inflammasome activation. Furthermore, we find that NiCo NCs inhibit neutrophil recruitment in an acute peritonitis mouse model and relieve symptoms in a colitis mouse model, again by inhibiting inflammasome activation. Beyond demonstrating a highly surprising and apparently therapeutic impact for an inorganic nanomaterial on inflammatory responses, our work suggests that nickel- and cobalt-containing nanomaterials may offer an opportunity to design anti-inflammatory nanomedicines for the therapeutics of macrophage-mediated diseases. |
format | Online Article Text |
id | pubmed-10406336 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-104063362023-08-08 Nickle-cobalt alloy nanocrystals inhibit activation of inflammasomes Lin, Jun Dong, Liang Liu, Yi-Ming Hu, Yi Jiang, Chen Liu, Ke Liu, Liu Song, Yong-Hong Sun, Mei Xiang, Xing-Cheng Qu, Kun Lu, Yang Wen, Long-Ping Yu, Shu-Hong Natl Sci Rev Research Article Activation of inflammasomes—immune system receptor sensor complexes that selectively activate inflammatory responses—has been associated with diverse human diseases, and many nanomedicine studies have reported that structurally and chemically diverse inorganic nanomaterials cause excessive inflammasome activation. Here, in stark contrast to reports of other inorganic nanomaterials, we find that nickel-cobalt alloy magnetic nanocrystals (NiCo NCs) actually inhibit activation of NLRP3, NLRC4 and AIM2 inflammasomes. We show that NiCo NCs disrupt the canonical inflammasome ASC speck formation process by downregulating the lncRNA Neat1, and experimentally confirm that the entry of NiCo NCs into cells is required for the observed inhibition of inflammasome activation. Furthermore, we find that NiCo NCs inhibit neutrophil recruitment in an acute peritonitis mouse model and relieve symptoms in a colitis mouse model, again by inhibiting inflammasome activation. Beyond demonstrating a highly surprising and apparently therapeutic impact for an inorganic nanomaterial on inflammatory responses, our work suggests that nickel- and cobalt-containing nanomaterials may offer an opportunity to design anti-inflammatory nanomedicines for the therapeutics of macrophage-mediated diseases. Oxford University Press 2023-06-26 /pmc/articles/PMC10406336/ /pubmed/37554586 http://dx.doi.org/10.1093/nsr/nwad179 Text en © The Author(s) 2023. Published by Oxford University Press on behalf of China Science Publishing & Media Ltd. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Lin, Jun Dong, Liang Liu, Yi-Ming Hu, Yi Jiang, Chen Liu, Ke Liu, Liu Song, Yong-Hong Sun, Mei Xiang, Xing-Cheng Qu, Kun Lu, Yang Wen, Long-Ping Yu, Shu-Hong Nickle-cobalt alloy nanocrystals inhibit activation of inflammasomes |
title | Nickle-cobalt alloy nanocrystals inhibit activation of inflammasomes |
title_full | Nickle-cobalt alloy nanocrystals inhibit activation of inflammasomes |
title_fullStr | Nickle-cobalt alloy nanocrystals inhibit activation of inflammasomes |
title_full_unstemmed | Nickle-cobalt alloy nanocrystals inhibit activation of inflammasomes |
title_short | Nickle-cobalt alloy nanocrystals inhibit activation of inflammasomes |
title_sort | nickle-cobalt alloy nanocrystals inhibit activation of inflammasomes |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10406336/ https://www.ncbi.nlm.nih.gov/pubmed/37554586 http://dx.doi.org/10.1093/nsr/nwad179 |
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