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Risk factors for multiple sclerosis in the context of Epstein-Barr virus infection
Compelling evidence indicates that Epstein Barr virus (EBV) infection is a prerequisite for multiple sclerosis (MS). The disease may arise from a complex interplay between latent EBV infection, genetic predisposition, and various environmental and lifestyle factors that negatively affect immune cont...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10406387/ https://www.ncbi.nlm.nih.gov/pubmed/37554326 http://dx.doi.org/10.3389/fimmu.2023.1212676 |
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author | Hedström, Anna Karin |
author_facet | Hedström, Anna Karin |
author_sort | Hedström, Anna Karin |
collection | PubMed |
description | Compelling evidence indicates that Epstein Barr virus (EBV) infection is a prerequisite for multiple sclerosis (MS). The disease may arise from a complex interplay between latent EBV infection, genetic predisposition, and various environmental and lifestyle factors that negatively affect immune control of the infection. Evidence of gene-environment interactions and epigenetic modifications triggered by environmental factors in genetically susceptible individuals supports this view. This review gives a short introduction to EBV and host immunity and discusses evidence indicating EBV as a prerequisite for MS. The role of genetic and environmental risk factors, and their interactions, in MS pathogenesis is reviewed and put in the context of EBV infection. Finally, possible preventive measures are discussed based on the findings presented. |
format | Online Article Text |
id | pubmed-10406387 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-104063872023-08-08 Risk factors for multiple sclerosis in the context of Epstein-Barr virus infection Hedström, Anna Karin Front Immunol Immunology Compelling evidence indicates that Epstein Barr virus (EBV) infection is a prerequisite for multiple sclerosis (MS). The disease may arise from a complex interplay between latent EBV infection, genetic predisposition, and various environmental and lifestyle factors that negatively affect immune control of the infection. Evidence of gene-environment interactions and epigenetic modifications triggered by environmental factors in genetically susceptible individuals supports this view. This review gives a short introduction to EBV and host immunity and discusses evidence indicating EBV as a prerequisite for MS. The role of genetic and environmental risk factors, and their interactions, in MS pathogenesis is reviewed and put in the context of EBV infection. Finally, possible preventive measures are discussed based on the findings presented. Frontiers Media S.A. 2023-07-24 /pmc/articles/PMC10406387/ /pubmed/37554326 http://dx.doi.org/10.3389/fimmu.2023.1212676 Text en Copyright © 2023 Hedström https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Hedström, Anna Karin Risk factors for multiple sclerosis in the context of Epstein-Barr virus infection |
title | Risk factors for multiple sclerosis in the context of Epstein-Barr virus infection |
title_full | Risk factors for multiple sclerosis in the context of Epstein-Barr virus infection |
title_fullStr | Risk factors for multiple sclerosis in the context of Epstein-Barr virus infection |
title_full_unstemmed | Risk factors for multiple sclerosis in the context of Epstein-Barr virus infection |
title_short | Risk factors for multiple sclerosis in the context of Epstein-Barr virus infection |
title_sort | risk factors for multiple sclerosis in the context of epstein-barr virus infection |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10406387/ https://www.ncbi.nlm.nih.gov/pubmed/37554326 http://dx.doi.org/10.3389/fimmu.2023.1212676 |
work_keys_str_mv | AT hedstromannakarin riskfactorsformultiplesclerosisinthecontextofepsteinbarrvirusinfection |