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The predictive value of left ventricular global longitudinal strain in normotensive critically ill septic patients
OBJECTIVE: Evaluation of left ventricular systolic function using speckle tracking echocardiography is more sensitive than conventional echocardiographic measurement in detecting subtle left ventricular dysfunction in septic patients. Our purpose was to investigate the predictive significance of lef...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Associação de Medicina Intensiva Brasileira - AMIB
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10406401/ https://www.ncbi.nlm.nih.gov/pubmed/37712808 http://dx.doi.org/10.5935/2965-2774.20230378-en |
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author | Omar, Timor İnci, Kamil Oflu, Yusuf Dilek, Mustafa Çelik, Zeynep Binici Kına, Soner İliş, Doğan Bucak, Halil Murat |
author_facet | Omar, Timor İnci, Kamil Oflu, Yusuf Dilek, Mustafa Çelik, Zeynep Binici Kına, Soner İliş, Doğan Bucak, Halil Murat |
author_sort | Omar, Timor |
collection | PubMed |
description | OBJECTIVE: Evaluation of left ventricular systolic function using speckle tracking echocardiography is more sensitive than conventional echocardiographic measurement in detecting subtle left ventricular dysfunction in septic patients. Our purpose was to investigate the predictive significance of left ventricular global longitudinal strain in normotensive septic intensive care patients. METHODS: This observational, prospective cohort study included septic normotensive adults admitted to the intensive care unit between June 1, 2021, and August 31, 2021. Left ventricular systolic function was measured using speckle-tracking echocardiography within 24 hours of admission. RESULTS: One hundred fifty-two patients were enrolled. The intensive care unit mortality rate was 27%. Left ventricular global longitudinal strain was less negative, which indicated worse left ventricular function in non-survivors than survivors (median [interquartile range], -15.2 [-17.2 - -12.5] versus -17.3 [-18.8 - -15.5]; p < 0.001). The optimal cutoff value for left ventricular global longitudinal strain was -17% in predicting intensive care unit mortality (area under the curve, 0.728). Patients with left ventricular global longitudinal strain > -17% (less negative than -17%, which indicated worse left ventricular function) showed a significantly higher mortality rate (39.2% versus 13.7%; p < 0.001). According to multivariate analysis, left ventricular global longitudinal strain was an independent predictor of intensive care unit mortality [OR (95%CI), 1.326 (1.038 - 1.693); p = 0.024], along with invasive mechanical ventilation and Glasgow coma scale, APACHE II, and SOFA risk scores. CONCLUSION: Impaired left ventricular global longitudinal strain is associated with mortality and provided predictive data in normotensive septic intensive care patients. |
format | Online Article Text |
id | pubmed-10406401 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Associação de Medicina Intensiva Brasileira - AMIB |
record_format | MEDLINE/PubMed |
spelling | pubmed-104064012023-08-08 The predictive value of left ventricular global longitudinal strain in normotensive critically ill septic patients Omar, Timor İnci, Kamil Oflu, Yusuf Dilek, Mustafa Çelik, Zeynep Binici Kına, Soner İliş, Doğan Bucak, Halil Murat Crit Care Sci Original Article OBJECTIVE: Evaluation of left ventricular systolic function using speckle tracking echocardiography is more sensitive than conventional echocardiographic measurement in detecting subtle left ventricular dysfunction in septic patients. Our purpose was to investigate the predictive significance of left ventricular global longitudinal strain in normotensive septic intensive care patients. METHODS: This observational, prospective cohort study included septic normotensive adults admitted to the intensive care unit between June 1, 2021, and August 31, 2021. Left ventricular systolic function was measured using speckle-tracking echocardiography within 24 hours of admission. RESULTS: One hundred fifty-two patients were enrolled. The intensive care unit mortality rate was 27%. Left ventricular global longitudinal strain was less negative, which indicated worse left ventricular function in non-survivors than survivors (median [interquartile range], -15.2 [-17.2 - -12.5] versus -17.3 [-18.8 - -15.5]; p < 0.001). The optimal cutoff value for left ventricular global longitudinal strain was -17% in predicting intensive care unit mortality (area under the curve, 0.728). Patients with left ventricular global longitudinal strain > -17% (less negative than -17%, which indicated worse left ventricular function) showed a significantly higher mortality rate (39.2% versus 13.7%; p < 0.001). According to multivariate analysis, left ventricular global longitudinal strain was an independent predictor of intensive care unit mortality [OR (95%CI), 1.326 (1.038 - 1.693); p = 0.024], along with invasive mechanical ventilation and Glasgow coma scale, APACHE II, and SOFA risk scores. CONCLUSION: Impaired left ventricular global longitudinal strain is associated with mortality and provided predictive data in normotensive septic intensive care patients. Associação de Medicina Intensiva Brasileira - AMIB 2023 /pmc/articles/PMC10406401/ /pubmed/37712808 http://dx.doi.org/10.5935/2965-2774.20230378-en Text en https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Omar, Timor İnci, Kamil Oflu, Yusuf Dilek, Mustafa Çelik, Zeynep Binici Kına, Soner İliş, Doğan Bucak, Halil Murat The predictive value of left ventricular global longitudinal strain in normotensive critically ill septic patients |
title | The predictive value of left ventricular global longitudinal strain
in normotensive critically ill septic patients |
title_full | The predictive value of left ventricular global longitudinal strain
in normotensive critically ill septic patients |
title_fullStr | The predictive value of left ventricular global longitudinal strain
in normotensive critically ill septic patients |
title_full_unstemmed | The predictive value of left ventricular global longitudinal strain
in normotensive critically ill septic patients |
title_short | The predictive value of left ventricular global longitudinal strain
in normotensive critically ill septic patients |
title_sort | predictive value of left ventricular global longitudinal strain
in normotensive critically ill septic patients |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10406401/ https://www.ncbi.nlm.nih.gov/pubmed/37712808 http://dx.doi.org/10.5935/2965-2774.20230378-en |
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