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The predictive value of left ventricular global longitudinal strain in normotensive critically ill septic patients

OBJECTIVE: Evaluation of left ventricular systolic function using speckle tracking echocardiography is more sensitive than conventional echocardiographic measurement in detecting subtle left ventricular dysfunction in septic patients. Our purpose was to investigate the predictive significance of lef...

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Autores principales: Omar, Timor, İnci, Kamil, Oflu, Yusuf, Dilek, Mustafa, Çelik, Zeynep Binici, Kına, Soner, İliş, Doğan, Bucak, Halil Murat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Associação de Medicina Intensiva Brasileira - AMIB 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10406401/
https://www.ncbi.nlm.nih.gov/pubmed/37712808
http://dx.doi.org/10.5935/2965-2774.20230378-en
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author Omar, Timor
İnci, Kamil
Oflu, Yusuf
Dilek, Mustafa
Çelik, Zeynep Binici
Kına, Soner
İliş, Doğan
Bucak, Halil Murat
author_facet Omar, Timor
İnci, Kamil
Oflu, Yusuf
Dilek, Mustafa
Çelik, Zeynep Binici
Kına, Soner
İliş, Doğan
Bucak, Halil Murat
author_sort Omar, Timor
collection PubMed
description OBJECTIVE: Evaluation of left ventricular systolic function using speckle tracking echocardiography is more sensitive than conventional echocardiographic measurement in detecting subtle left ventricular dysfunction in septic patients. Our purpose was to investigate the predictive significance of left ventricular global longitudinal strain in normotensive septic intensive care patients. METHODS: This observational, prospective cohort study included septic normotensive adults admitted to the intensive care unit between June 1, 2021, and August 31, 2021. Left ventricular systolic function was measured using speckle-tracking echocardiography within 24 hours of admission. RESULTS: One hundred fifty-two patients were enrolled. The intensive care unit mortality rate was 27%. Left ventricular global longitudinal strain was less negative, which indicated worse left ventricular function in non-survivors than survivors (median [interquartile range], -15.2 [-17.2 - -12.5] versus -17.3 [-18.8 - -15.5]; p < 0.001). The optimal cutoff value for left ventricular global longitudinal strain was -17% in predicting intensive care unit mortality (area under the curve, 0.728). Patients with left ventricular global longitudinal strain > -17% (less negative than -17%, which indicated worse left ventricular function) showed a significantly higher mortality rate (39.2% versus 13.7%; p < 0.001). According to multivariate analysis, left ventricular global longitudinal strain was an independent predictor of intensive care unit mortality [OR (95%CI), 1.326 (1.038 - 1.693); p = 0.024], along with invasive mechanical ventilation and Glasgow coma scale, APACHE II, and SOFA risk scores. CONCLUSION: Impaired left ventricular global longitudinal strain is associated with mortality and provided predictive data in normotensive septic intensive care patients.
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spelling pubmed-104064012023-08-08 The predictive value of left ventricular global longitudinal strain in normotensive critically ill septic patients Omar, Timor İnci, Kamil Oflu, Yusuf Dilek, Mustafa Çelik, Zeynep Binici Kına, Soner İliş, Doğan Bucak, Halil Murat Crit Care Sci Original Article OBJECTIVE: Evaluation of left ventricular systolic function using speckle tracking echocardiography is more sensitive than conventional echocardiographic measurement in detecting subtle left ventricular dysfunction in septic patients. Our purpose was to investigate the predictive significance of left ventricular global longitudinal strain in normotensive septic intensive care patients. METHODS: This observational, prospective cohort study included septic normotensive adults admitted to the intensive care unit between June 1, 2021, and August 31, 2021. Left ventricular systolic function was measured using speckle-tracking echocardiography within 24 hours of admission. RESULTS: One hundred fifty-two patients were enrolled. The intensive care unit mortality rate was 27%. Left ventricular global longitudinal strain was less negative, which indicated worse left ventricular function in non-survivors than survivors (median [interquartile range], -15.2 [-17.2 - -12.5] versus -17.3 [-18.8 - -15.5]; p < 0.001). The optimal cutoff value for left ventricular global longitudinal strain was -17% in predicting intensive care unit mortality (area under the curve, 0.728). Patients with left ventricular global longitudinal strain > -17% (less negative than -17%, which indicated worse left ventricular function) showed a significantly higher mortality rate (39.2% versus 13.7%; p < 0.001). According to multivariate analysis, left ventricular global longitudinal strain was an independent predictor of intensive care unit mortality [OR (95%CI), 1.326 (1.038 - 1.693); p = 0.024], along with invasive mechanical ventilation and Glasgow coma scale, APACHE II, and SOFA risk scores. CONCLUSION: Impaired left ventricular global longitudinal strain is associated with mortality and provided predictive data in normotensive septic intensive care patients. Associação de Medicina Intensiva Brasileira - AMIB 2023 /pmc/articles/PMC10406401/ /pubmed/37712808 http://dx.doi.org/10.5935/2965-2774.20230378-en Text en https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Omar, Timor
İnci, Kamil
Oflu, Yusuf
Dilek, Mustafa
Çelik, Zeynep Binici
Kına, Soner
İliş, Doğan
Bucak, Halil Murat
The predictive value of left ventricular global longitudinal strain in normotensive critically ill septic patients
title The predictive value of left ventricular global longitudinal strain in normotensive critically ill septic patients
title_full The predictive value of left ventricular global longitudinal strain in normotensive critically ill septic patients
title_fullStr The predictive value of left ventricular global longitudinal strain in normotensive critically ill septic patients
title_full_unstemmed The predictive value of left ventricular global longitudinal strain in normotensive critically ill septic patients
title_short The predictive value of left ventricular global longitudinal strain in normotensive critically ill septic patients
title_sort predictive value of left ventricular global longitudinal strain in normotensive critically ill septic patients
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10406401/
https://www.ncbi.nlm.nih.gov/pubmed/37712808
http://dx.doi.org/10.5935/2965-2774.20230378-en
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