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A pilot phase Ib study to evaluate tadalafil to overcome immunosuppression during chemoradiotherapy for IDH-wild-type glioblastoma

BACKGROUND: Myeloid-derived suppressor cells (MDSCs) are critical regulators of immunosuppression and radioresistance in glioblastoma (GBM). The primary objective of this pilot phase Ib study was to validate the on-target effect of tadalafil on inhibiting MDSCs in peripheral blood and its safety whe...

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Detalles Bibliográficos
Autores principales:	Ghosh, Subhajit, Johanns, Tanner M, Chheda, Milan G, Liu, Eric, Butt, Omar, Abraham, Christopher, Badiyan, Shahed, Huang, Yi, DeNardo, David, Kim, Albert H, Hallahan, Dennis, Thotala, Dinesh, Huang, Jiayi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2023
Materias:	Clinical Investigations
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10406429/ https://www.ncbi.nlm.nih.gov/pubmed/37554225 http://dx.doi.org/10.1093/noajnl/vdad088

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