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Phase I dose-escalation study of procaspase-activating compound-1 in combination with temozolomide in patients with recurrent high-grade astrocytomas

BACKGROUND: Procaspase-3 (PC-3) is overexpressed in various tumor types, including gliomas. Targeted PC-3 activation combined with chemotherapy is a novel strategy for treating patients with high-grade gliomas, with promising preclinical activity. This study aimed to define safety and tolerability o...

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Detalles Bibliográficos
Autores principales:	Holdhoff, Matthias, Nicholas, M Kelly, Peterson, Richard A, Maraka, Stefania, Liu, Li C, Fischer, James H, Wefel, Jeffrey S, Fan, Timothy M, Vannorsdall, Tracy, Russell, Meredith, Iacoboni, Michaella, Tarasow, Theodore M, Hergenrother, Paul J, Dudek, Arkadiusz Z, Danciu, Oana C
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2023
Materias:	Clinical Investigations
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10406430/ https://www.ncbi.nlm.nih.gov/pubmed/37554223 http://dx.doi.org/10.1093/noajnl/vdad087

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