Regulation of store-operated Ca(2+) entry by IP(3) receptors independent of their ability to release Ca(2+)

Loss of endoplasmic reticular (ER) Ca(2+) activates store-operated Ca(2+) entry (SOCE) by causing the ER localized Ca(2+) sensor STIM to unfurl domains that activate Orai channels in the plasma membrane at membrane contact sites (MCS). Here, we demonstrate a novel mechanism by which the inositol 1,4...

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Detalles Bibliográficos
Autores principales: Chakraborty, Pragnya, Deb, Bipan Kumar, Arige, Vikas, Musthafa, Thasneem, Malik, Sundeep, Yule, David I, Taylor, Colin W, Hasan, Gaiti
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10406432/
https://www.ncbi.nlm.nih.gov/pubmed/37466241
http://dx.doi.org/10.7554/eLife.80447

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10406432/
https://www.ncbi.nlm.nih.gov/pubmed/37466241
http://dx.doi.org/10.7554/eLife.80447

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