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PC4-mediated Ku complex PARylation facilitates NHEJ-dependent DNA damage repair

Radiotherapy is one of the mainstay treatments for hepatocellular carcinoma (HCC). However, a substantial number of patients with HCC develop radioresistance and eventually suffer from tumor progression or relapse, which is a major impediment to the use of radiotherapy. Therefore, elucidating the me...

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Detalles Bibliográficos
Autores principales:	Pan, Qimei, Luo, Peng, Shi, Chunmeng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10406618/ https://www.ncbi.nlm.nih.gov/pubmed/37437887 http://dx.doi.org/10.1016/j.jbc.2023.105032

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