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A formamidopyrimidine derivative from the deoxyguanosine adduct produced by food contaminant acrylamide induces DNA replication block and mutagenesis

Acrylamide, a common food contaminant, is metabolically activated to glycidamide, which reacts with DNA at the N7 position of dG, forming N7-(2-carbamoyl-2-hydroxyethyl)-dG (GA(7)dG). Owing to its chemical lability, the mutagenic potency of GA(7)dG has not yet been clarified. We found that GA(7)dG u...

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Detalles Bibliográficos
Autores principales:	Akagi, Jun-ichi, Yokoi, Masayuki, Miyake, Yumi, Shirai, Tsuyoshi, Baba, Tomohiro, Cho, Young-Man, Hanaoka, Fumio, Sugasawa, Kaoru, Iwai, Shigenori, Ogawa, Kumiko
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10406624/ https://www.ncbi.nlm.nih.gov/pubmed/37394003 http://dx.doi.org/10.1016/j.jbc.2023.105002

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