Antigen-dependent IL-12 signaling in CAR T cells promotes regional to systemic disease targeting

Chimeric antigen receptor (CAR) T cell therapeutic responses are hampered by limited T cell trafficking, persistence, and durable anti-tumor activity in solid tumors. However, these challenges can be largely overcome by relatively unconstrained synthetic engineering strategies. Here, we describe CAR...

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Detalles Bibliográficos
Autores principales: Lee, Eric Hee Jun, Murad, John P., Christian, Lea, Gibson, Jackson, Yamaguchi, Yukiko, Cullen, Cody, Gumber, Diana, Park, Anthony K., Young, Cari, Monroy, Isabel, Yang, Jason, Stern, Lawrence A., Adkins, Lauren N., Dhapola, Gaurav, Gittins, Brenna, Chang, Wen-Chung, Martinez, Catalina, Woo, Yanghee, Cristea, Mihaela, Rodriguez-Rodriguez, Lorna, Ishihara, Jun, Lee, John K., Forman, Stephen J., Wang, Leo D., Priceman, Saul J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10406808/
https://www.ncbi.nlm.nih.gov/pubmed/37550294
http://dx.doi.org/10.1038/s41467-023-40115-1

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