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Backbone spiking sequence as a basis for preplay, replay, and default states in human cortex
Sequences of spiking activity have been heavily implicated as potential substrates of memory formation and retrieval across many species. A parallel line of recent evidence also asserts that sequential activity may arise from and be constrained by pre-existing network structure. Here we reconcile th...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10406814/ https://www.ncbi.nlm.nih.gov/pubmed/37550285 http://dx.doi.org/10.1038/s41467-023-40440-5 |
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author | Vaz, Alex P. Wittig, John H. Inati, Sara K. Zaghloul, Kareem A. |
author_facet | Vaz, Alex P. Wittig, John H. Inati, Sara K. Zaghloul, Kareem A. |
author_sort | Vaz, Alex P. |
collection | PubMed |
description | Sequences of spiking activity have been heavily implicated as potential substrates of memory formation and retrieval across many species. A parallel line of recent evidence also asserts that sequential activity may arise from and be constrained by pre-existing network structure. Here we reconcile these two lines of research in the human brain by measuring single unit spiking sequences in the temporal lobe cortex as participants perform an episodic memory task. We find the presence of an average backbone spiking sequence identified during pre-task rest that is stable over time and different cognitive states. We further demonstrate that these backbone sequences are composed of both rigid and flexible sequence elements, and that flexible elements within these sequences serve to promote memory specificity when forming and retrieving new memories. These results support the hypothesis that pre-existing network dynamics serve as a scaffold for ongoing neural activity in the human cortex. |
format | Online Article Text |
id | pubmed-10406814 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-104068142023-08-09 Backbone spiking sequence as a basis for preplay, replay, and default states in human cortex Vaz, Alex P. Wittig, John H. Inati, Sara K. Zaghloul, Kareem A. Nat Commun Article Sequences of spiking activity have been heavily implicated as potential substrates of memory formation and retrieval across many species. A parallel line of recent evidence also asserts that sequential activity may arise from and be constrained by pre-existing network structure. Here we reconcile these two lines of research in the human brain by measuring single unit spiking sequences in the temporal lobe cortex as participants perform an episodic memory task. We find the presence of an average backbone spiking sequence identified during pre-task rest that is stable over time and different cognitive states. We further demonstrate that these backbone sequences are composed of both rigid and flexible sequence elements, and that flexible elements within these sequences serve to promote memory specificity when forming and retrieving new memories. These results support the hypothesis that pre-existing network dynamics serve as a scaffold for ongoing neural activity in the human cortex. Nature Publishing Group UK 2023-08-07 /pmc/articles/PMC10406814/ /pubmed/37550285 http://dx.doi.org/10.1038/s41467-023-40440-5 Text en © This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Vaz, Alex P. Wittig, John H. Inati, Sara K. Zaghloul, Kareem A. Backbone spiking sequence as a basis for preplay, replay, and default states in human cortex |
title | Backbone spiking sequence as a basis for preplay, replay, and default states in human cortex |
title_full | Backbone spiking sequence as a basis for preplay, replay, and default states in human cortex |
title_fullStr | Backbone spiking sequence as a basis for preplay, replay, and default states in human cortex |
title_full_unstemmed | Backbone spiking sequence as a basis for preplay, replay, and default states in human cortex |
title_short | Backbone spiking sequence as a basis for preplay, replay, and default states in human cortex |
title_sort | backbone spiking sequence as a basis for preplay, replay, and default states in human cortex |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10406814/ https://www.ncbi.nlm.nih.gov/pubmed/37550285 http://dx.doi.org/10.1038/s41467-023-40440-5 |
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