The role of epithelial-mesenchymal transition and autophagy in pancreatic ductal adenocarcinoma invasion

Of all pancreatic cancer (PC) cases, approximately 90% are pancreatic ductal adenocarcinoma (PDAC), which progress rapidly due to its high degree of invasiveness and high metastatic potential. Epithelial-mesenchymal transition (EMT) is a prerequisite for cancer cell invasion and spread, and it is me...

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Detalles Bibliográficos
Autores principales: Yang, Jian, Liu, Ying, Liu, Shi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10406904/
https://www.ncbi.nlm.nih.gov/pubmed/37550301
http://dx.doi.org/10.1038/s41419-023-06032-3
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author Yang, Jian
Liu, Ying
Liu, Shi
author_facet Yang, Jian
Liu, Ying
Liu, Shi
author_sort Yang, Jian
collection PubMed
description Of all pancreatic cancer (PC) cases, approximately 90% are pancreatic ductal adenocarcinoma (PDAC), which progress rapidly due to its high degree of invasiveness and high metastatic potential. Epithelial-mesenchymal transition (EMT) is a prerequisite for cancer cell invasion and spread, and it is mediated by the specific cellular behaviors and the tumor microenvironment. Autophagy has long been a target of cancer therapy, and it has been considered to play a dual and contradictory role, particularly regarding EMT-mediated PDAC invasion. This review discusses the characteristics and the biological role of EMT and autophagy from a cellular perspective, explaining invasion as a survival behavior of PDAC, with the aim of providing novel insights into targeting EMT and autophagy to overcome PDAC invasion.
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spelling pubmed-104069042023-08-09 The role of epithelial-mesenchymal transition and autophagy in pancreatic ductal adenocarcinoma invasion Yang, Jian Liu, Ying Liu, Shi Cell Death Dis Review Article Of all pancreatic cancer (PC) cases, approximately 90% are pancreatic ductal adenocarcinoma (PDAC), which progress rapidly due to its high degree of invasiveness and high metastatic potential. Epithelial-mesenchymal transition (EMT) is a prerequisite for cancer cell invasion and spread, and it is mediated by the specific cellular behaviors and the tumor microenvironment. Autophagy has long been a target of cancer therapy, and it has been considered to play a dual and contradictory role, particularly regarding EMT-mediated PDAC invasion. This review discusses the characteristics and the biological role of EMT and autophagy from a cellular perspective, explaining invasion as a survival behavior of PDAC, with the aim of providing novel insights into targeting EMT and autophagy to overcome PDAC invasion. Nature Publishing Group UK 2023-08-07 /pmc/articles/PMC10406904/ /pubmed/37550301 http://dx.doi.org/10.1038/s41419-023-06032-3 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review Article
Yang, Jian
Liu, Ying
Liu, Shi
The role of epithelial-mesenchymal transition and autophagy in pancreatic ductal adenocarcinoma invasion
title The role of epithelial-mesenchymal transition and autophagy in pancreatic ductal adenocarcinoma invasion
title_full The role of epithelial-mesenchymal transition and autophagy in pancreatic ductal adenocarcinoma invasion
title_fullStr The role of epithelial-mesenchymal transition and autophagy in pancreatic ductal adenocarcinoma invasion
title_full_unstemmed The role of epithelial-mesenchymal transition and autophagy in pancreatic ductal adenocarcinoma invasion
title_short The role of epithelial-mesenchymal transition and autophagy in pancreatic ductal adenocarcinoma invasion
title_sort role of epithelial-mesenchymal transition and autophagy in pancreatic ductal adenocarcinoma invasion
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10406904/
https://www.ncbi.nlm.nih.gov/pubmed/37550301
http://dx.doi.org/10.1038/s41419-023-06032-3
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