TET2 is required to suppress mTORC1 signaling through urea cycle with therapeutic potential

Tumor development, involving both cell growth (mass accumulation) and cell proliferation, is a complex process governed by the interplay of multiple signaling pathways. TET2 mainly functions as a DNA dioxygenase, which modulates gene expression and biological functions via oxidation of 5mC in DNA, y...

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Detalles Bibliográficos
Autores principales: He, Jing, Lin, Mingen, Zhang, Xinchao, Zhang, Ruonan, Tian, Tongguan, Zhou, Yuefan, Dong, Wenjing, Yang, Yajing, Sun, Xue, Dai, Yue, Xu, Yue, Zhang, Zhenru, Xu, Ming, Lei, Qun-Ying, Xu, Yanping, Lv, Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Nature Singapore 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10406918/
https://www.ncbi.nlm.nih.gov/pubmed/37550284
http://dx.doi.org/10.1038/s41421-023-00567-7

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