A conformational rearrangement of the SARS-CoV-2 host protein sigma-1 is required for antiviral activity: insights from a combined in-silico/in-vitro approach

The development of effective drugs to treat coronavirus infections remains a significant challenge for the scientific community. Recent evidence reports on the sigma-1 receptor (S1R) as a key druggable host protein in the SARS-CoV-1 and SARS-CoV-2 interactomes and shows a potent antiviral activity a...

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Detalles Bibliográficos
Autores principales: Abatematteo, Francesca Serena, Delre, Pietro, Mercurio, Ivan, Rezelj, Veronica V., Siliqi, Dritan, Beaucourt, Stephanie, Lattanzi, Gianluca, Colabufo, Nicola Antonio, Leopoldo, Marcello, Saviano, Michele, Vignuzzi, Marco, Mangiatordi, Giuseppe Felice, Abate, Carmen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10406941/
https://www.ncbi.nlm.nih.gov/pubmed/37550340
http://dx.doi.org/10.1038/s41598-023-39662-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10406941/
https://www.ncbi.nlm.nih.gov/pubmed/37550340
http://dx.doi.org/10.1038/s41598-023-39662-w

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