Cargando…

A conformational rearrangement of the SARS-CoV-2 host protein sigma-1 is required for antiviral activity: insights from a combined in-silico/in-vitro approach

The development of effective drugs to treat coronavirus infections remains a significant challenge for the scientific community. Recent evidence reports on the sigma-1 receptor (S1R) as a key druggable host protein in the SARS-CoV-1 and SARS-CoV-2 interactomes and shows a potent antiviral activity a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Abatematteo, Francesca Serena, Delre, Pietro, Mercurio, Ivan, Rezelj, Veronica V., Siliqi, Dritan, Beaucourt, Stephanie, Lattanzi, Gianluca, Colabufo, Nicola Antonio, Leopoldo, Marcello, Saviano, Michele, Vignuzzi, Marco, Mangiatordi, Giuseppe Felice, Abate, Carmen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10406941/ https://www.ncbi.nlm.nih.gov/pubmed/37550340 http://dx.doi.org/10.1038/s41598-023-39662-w

Ejemplares similares

A Comparative Molecular Dynamics Study of Selected Point Mutations in the Shwachman–Bodian–Diamond Syndrome Protein SBDS
por: Spinetti, Elena, et al.
Publicado: (2022)

PB28, the Sigma-1 and Sigma-2 Receptors Modulator With Potent Anti–SARS-CoV-2 Activity: A Review About Its Pharmacological Properties and Structure Affinity Relationships
por: Abate, Carmen, et al.
Publicado: (2020)

Repurposing Known Drugs as Covalent and Non-covalent Inhibitors of the SARS-CoV-2 Papain-Like Protease
por: Delre, Pietro, et al.
Publicado: (2020)

Structure-Based Prediction of hERG-Related Cardiotoxicity: A Benchmark Study
por: Creanza, Teresa Maria, et al.
Publicado: (2021)

GENERA: A Combined Genetic/Deep-Learning Algorithm for Multiobjective Target-Oriented De Novo Design
por: Lamanna, Giuseppe, et al.
Publicado: (2023)

Development of Fluorescent 4-[4-(3H-Spiro[isobenzofuran-1,4′-piperidin]-1′-yl)butyl]indolyl Derivatives as High-Affinity Probes to Enable the Study of σ Receptors via Fluorescence-Based Techniques
por: Abatematteo, Francesca Serena, et al.
Publicado: (2023)

More Is Always Better Than One: The N-Terminal Domain of the Spike Protein as Another Emerging Target for Hampering the SARS-CoV-2 Attachment to Host Cells
por: Di Gaetano, Sonia, et al.
Publicado: (2021)

Ligand-based prediction of hERG-mediated cardiotoxicity based on the integration of different machine learning techniques
por: Delre, Pietro, et al.
Publicado: (2022)

Crystallographic study of PET radiotracers in clinical evaluation for early diagnosis of Alzheimers
por: Altomare, Angela, et al.
Publicado: (2014)

Multifunctional thiosemicarbazones targeting sigma receptors: in vitro and in vivo antitumor activities in pancreatic cancer models
por: Niso, Mauro, et al.
Publicado: (2021)

X-ray Characterization of Conformational Changes of Human Apo- and Holo-Transferrin
por: Campos-Escamilla, Camila, et al.
Publicado: (2021)

Endocannabinoid Degradation Enzyme Inhibitors as Potential Antipsychotics: A Medicinal Chemistry Perspective
por: Mangiatordi, Giuseppe Felice, et al.
Publicado: (2023)

Interaction of the GTPase Elongation Factor Like-1 with the Shwachman-Diamond Syndrome Protein and Its Missense Mutations
por: Gijsbers, Abril, et al.
Publicado: (2018)

Multi-Target Directed Ligands (MTDLs) Binding the σ(1) Receptor as Promising Therapeutics: State of the Art and Perspectives
por: Abatematteo, Francesca Serena, et al.
Publicado: (2021)

Modelling Degradation and Replication Kinetics of the Zika Virus In Vitro Infection
por: Bernhauerová, Veronika, et al.
Publicado: (2020)

Organic bioelectronics probing conformational changes in surface confined proteins
por: Macchia, Eleonora, et al.
Publicado: (2016)

Human Aquaporin-4 and Molecular Modeling: Historical Perspective and View to the Future
por: Mangiatordi, Giuseppe Felice, et al.
Publicado: (2016)

Mathematical modelling of SARS-CoV-2 infection of human and animal host cells reveals differences in the infection rates and delays in viral particle production by infected cells
por: Bernhauerová, Veronika, et al.
Publicado: (2021)

Ribavirin: a drug active against many viruses with multiple effects on virus replication and propagation. Molecular basis of ribavirin resistance
por: Beaucourt, Stéphanie, et al.
Publicado: (2014)

The Intriguing Sigma-1 and Sigma-2 Receptors and Their Potential Therapeutic Roles 2.0
por: Abate, Carmen, et al.
Publicado: (2023)

The effect of chemical structure of carboxylate molecules on hydroxyapatite nanoparticles. A structural and morphological study
por: Degli Esposti, Lorenzo, et al.
Publicado: (2021)

Sigma-2 Receptor Ligand Binding Modulates Association between TSPO and TMEM97
por: Thejer, Bashar M., et al.
Publicado: (2023)

Dynamically restoring conformal invariance in (integrable) $\sigma$-models
por: Aliaj, Rigers, et al.
Publicado: (2022)

Defective viral genomes from chikungunya virus are broad-spectrum antivirals and prevent virus dissemination in mosquitoes
por: Levi, Laura I., et al.
Publicado: (2021)

σ(2) Receptor and Its Role in Cancer with Focus on a MultiTarget Directed Ligand (MTDL) Approach
por: Abatematteo, Francesca Serena, et al.
Publicado: (2021)

Two-dimensional conformal sigma models and exact string solutions
por: Tseytlin, Arkady A.
Publicado: (1993)

Sequential conformational rearrangements in flavivirus membrane fusion
por: Chao, Luke H, et al.
Publicado: (2014)

Conformal sigma models corresponding to gauged Wess-Zumino - Witten theories
por: Tseytlin, Arkady A.
Publicado: (1994)

Conformal anomaly in two-dimensional sigma-model on curved background and strings
por: Tseytlin, Arkady A
Publicado: (1986)

New Insights into the Behavior of NHC-Gold Complexes in Cancer Cells
por: Augello, Giuseppa, et al.
Publicado: (2023)

Correction: Sequential conformational rearrangements in flavivirus membrane fusion
por: Chao, Luke H, et al.
Publicado: (2015)

The systematic approach to describing conformational rearrangements in G-quadruplexes
por: Tsvetkov, Vladimir, et al.
Publicado: (2016)

Coherent Diffraction Imaging in Transmission Electron Microscopy for Atomic Resolution Quantitative Studies of the Matter
por: Carlino, Elvio, et al.
Publicado: (2018)

Table-top combined scanning X-ray small angle scattering and transmission microscopies of lipid vesicles dispersed in free-standing gel
por: Scattarella, Francesco, et al.
Publicado: (2020)

Adamantane-derived scaffolds targeting the sigma-2 receptor; an in vitro and in silico study
por: Alamri, Mohammed A., et al.
Publicado: (2021)

Novel Insights into Conformational Rearrangements of the Bacterial Flagellar Switch Complex
por: Sakai, Tomofumi, et al.
Publicado: (2019)

Conformational rearrangement during activation of a metabotropic glutamate receptor
por: Liauw, Brandon Wey-Hung, et al.
Publicado: (2021)

Conformational Rearrangements Regulating the DNA Repair Protein APE1
por: Komaniecka, Nina, et al.
Publicado: (2022)

Structural Insights on Tiny Peptide Nucleic Acid (PNA) Analogues of miRNA-34a: An in silico and Experimental Integrated Approach
por: Moccia, Maria, et al.
Publicado: (2020)

Ptychographic Imaging of Branched Colloidal Nanocrystals Embedded in Free-Standing Thick Polystyrene Films
por: De Caro, Liberato, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_5qkc65vmq4ep6phofrucr95evd