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The role of Mycobacterium tuberculosis acetyltransferase and protein acetylation modifications in tuberculosis

Tuberculosis (TB) is a widespread infectious disease caused by Mycobacterium tuberculosis (M. tb), which has been a significant burden for a long time. Post-translational modifications (PTMs) are essential for protein function in both eukaryotic and prokaryotic cells. This review focuses on the cont...

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Autores principales: Huang, Yinxia, Zhu, Chuanzhi, Pan, Liping, Zhang, Zongde
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10407107/
https://www.ncbi.nlm.nih.gov/pubmed/37560320
http://dx.doi.org/10.3389/fcimb.2023.1218583
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author Huang, Yinxia
Zhu, Chuanzhi
Pan, Liping
Zhang, Zongde
author_facet Huang, Yinxia
Zhu, Chuanzhi
Pan, Liping
Zhang, Zongde
author_sort Huang, Yinxia
collection PubMed
description Tuberculosis (TB) is a widespread infectious disease caused by Mycobacterium tuberculosis (M. tb), which has been a significant burden for a long time. Post-translational modifications (PTMs) are essential for protein function in both eukaryotic and prokaryotic cells. This review focuses on the contribution of protein acetylation to the function of M. tb and its infected macrophages. The acetylation of M. tb proteins plays a critical role in virulence, drug resistance, regulation of metabolism, and host anti-TB immune response. Similarly, the PTMs of host proteins induced by M. tb are crucial for the development, treatment, and prevention of diseases. Host protein acetylation induced by M. tb is significant in regulating host immunity against TB, which substantially affects the disease’s development. The review summarizes the functions and mechanisms of M. tb acetyltransferase in virulence and drug resistance. It also discusses the role and mechanism of M. tb in regulating host protein acetylation and immune response regulation. Furthermore, the current scenario of isoniazid usage in M. tb therapy treatment is examined. Overall, this review provides valuable information that can serve as a preliminary basis for studying pathogenic research, developing new drugs, exploring in-depth drug resistance mechanisms, and providing precise treatment for TB.
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spelling pubmed-104071072023-08-09 The role of Mycobacterium tuberculosis acetyltransferase and protein acetylation modifications in tuberculosis Huang, Yinxia Zhu, Chuanzhi Pan, Liping Zhang, Zongde Front Cell Infect Microbiol Cellular and Infection Microbiology Tuberculosis (TB) is a widespread infectious disease caused by Mycobacterium tuberculosis (M. tb), which has been a significant burden for a long time. Post-translational modifications (PTMs) are essential for protein function in both eukaryotic and prokaryotic cells. This review focuses on the contribution of protein acetylation to the function of M. tb and its infected macrophages. The acetylation of M. tb proteins plays a critical role in virulence, drug resistance, regulation of metabolism, and host anti-TB immune response. Similarly, the PTMs of host proteins induced by M. tb are crucial for the development, treatment, and prevention of diseases. Host protein acetylation induced by M. tb is significant in regulating host immunity against TB, which substantially affects the disease’s development. The review summarizes the functions and mechanisms of M. tb acetyltransferase in virulence and drug resistance. It also discusses the role and mechanism of M. tb in regulating host protein acetylation and immune response regulation. Furthermore, the current scenario of isoniazid usage in M. tb therapy treatment is examined. Overall, this review provides valuable information that can serve as a preliminary basis for studying pathogenic research, developing new drugs, exploring in-depth drug resistance mechanisms, and providing precise treatment for TB. Frontiers Media S.A. 2023-07-25 /pmc/articles/PMC10407107/ /pubmed/37560320 http://dx.doi.org/10.3389/fcimb.2023.1218583 Text en Copyright © 2023 Huang, Zhu, Pan and Zhang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cellular and Infection Microbiology
Huang, Yinxia
Zhu, Chuanzhi
Pan, Liping
Zhang, Zongde
The role of Mycobacterium tuberculosis acetyltransferase and protein acetylation modifications in tuberculosis
title The role of Mycobacterium tuberculosis acetyltransferase and protein acetylation modifications in tuberculosis
title_full The role of Mycobacterium tuberculosis acetyltransferase and protein acetylation modifications in tuberculosis
title_fullStr The role of Mycobacterium tuberculosis acetyltransferase and protein acetylation modifications in tuberculosis
title_full_unstemmed The role of Mycobacterium tuberculosis acetyltransferase and protein acetylation modifications in tuberculosis
title_short The role of Mycobacterium tuberculosis acetyltransferase and protein acetylation modifications in tuberculosis
title_sort role of mycobacterium tuberculosis acetyltransferase and protein acetylation modifications in tuberculosis
topic Cellular and Infection Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10407107/
https://www.ncbi.nlm.nih.gov/pubmed/37560320
http://dx.doi.org/10.3389/fcimb.2023.1218583
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