Comparison of activity, structure, and dynamics of SF-1 and LRH-1 complexed with small molecule modulators

Steroidogenic factor-1 (SF-1) is a phospholipid-sensing nuclear receptor expressed in the adrenal glands, gonads, and hypothalamus which controls steroidogenesis and metabolism. There is significant therapeutic interest in SF-1 because of its oncogenic properties in adrenocortical cancer. Synthetic...

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Detalles Bibliográficos
Autores principales: Cato, Michael L., D’Agostino, Emma H., Spurlin, Racheal M., Flynn, Autumn R., Cornelison, Jeffery L., Johnson, Alyssa M., Fujita, Rei A., Abraham, Sarah M., Jui, Nathan T., Ortlund, Eric A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10407255/
https://www.ncbi.nlm.nih.gov/pubmed/37328104
http://dx.doi.org/10.1016/j.jbc.2023.104921

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