Single-cell sequencing on CD8(+) TILs revealed the nature of exhausted T cells recognizing neoantigen and cancer/testis antigen in non-small cell lung cancer

BACKGROUND: CD8(+)tumor infiltrating lymphocytes (TILs) are often observed in non-small cell lung cancers (NSCLC). However, the characteristics of CD8(+) TILs, especially T-cell populations specific for tumor antigens, remain poorly understood. METHODS: High throughput single-cell RNA sequencing and...

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Detalles Bibliográficos
Autores principales: Komuro, Hiroyasu, Shinohara, Shuichi, Fukushima, Yasunori, Demachi-Okamura, Ayako, Muraoka, Daisuke, Masago, Katsuhiro, Matsui, Takuya, Sugita, Yusuke, Takahashi, Yusuke, Nishida, Reina, Takashima, Chieko, Ohki, Takashi, Shigematsu, Yoshiki, Watanabe, Fumiaki, Adachi, Katsutoshi, Fukuyama, Takashi, Hamana, Hiroshi, Kishi, Hiroyuki, Miura, Daiki, Tanaka, Yuki, Onoue, Kousuke, Onoguchi, Kazuhide, Yamashita, Yoshiko, Stratford, Richard, Clancy, Trevor, Yamaguchi, Rui, Kuroda, Hiroaki, Doi, Kiyoshi, Iwata, Hisashi, Matsushita, Hirokazu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2023
Materias:
Basic Tumor Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10407349/
https://www.ncbi.nlm.nih.gov/pubmed/37544663
http://dx.doi.org/10.1136/jitc-2023-007180

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