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Oncolytic viruses and antibodies: are they more successful when delivered separately or when engineered as a single agent?

Oncolytic viruses (OVs) provide the promise of tumor-selective cytotoxicity coupled with amplification of the therapeutic agent (the virus) in situ within the tumor improving its therapeutic index. Despite this promise, however, single agent-treatments have not been as successful as combination ther...

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Detalles Bibliográficos
Autores principales: Wan, Peter Kok-Ting, Fernandes, Ricardo A, Seymour, Leonard W
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10407364/
https://www.ncbi.nlm.nih.gov/pubmed/37541690
http://dx.doi.org/10.1136/jitc-2022-006518