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Oxford brain health clinic: protocol and research database
INTRODUCTION: Despite major advances in the field of neuroscience over the last three decades, the quality of assessments available to patients with memory problems in later life has barely changed. At the same time, a large proportion of dementia biomarker research is conducted in selected research...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10407419/ https://www.ncbi.nlm.nih.gov/pubmed/37541753 http://dx.doi.org/10.1136/bmjopen-2022-067808 |
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author | O'Donoghue, Melissa Clare Blane, Jasmine Gillis, Grace Mitchell, Robert Lindsay, Karen Semple, Juliet Pretorius, Pieter M Griffanti, Ludovica Fossey, Jane Raymont, Vanessa Martos, Lola Mackay, Clare E |
author_facet | O'Donoghue, Melissa Clare Blane, Jasmine Gillis, Grace Mitchell, Robert Lindsay, Karen Semple, Juliet Pretorius, Pieter M Griffanti, Ludovica Fossey, Jane Raymont, Vanessa Martos, Lola Mackay, Clare E |
author_sort | O'Donoghue, Melissa Clare |
collection | PubMed |
description | INTRODUCTION: Despite major advances in the field of neuroscience over the last three decades, the quality of assessments available to patients with memory problems in later life has barely changed. At the same time, a large proportion of dementia biomarker research is conducted in selected research samples that often poorly reflect the demographics of the population of patients who present to memory clinics. The Oxford Brain Health Clinic (BHC) is a newly developed clinical assessment service with embedded research in which all patients are offered high-quality clinical and research assessments, including MRI, as standard. METHODS AND ANALYSIS: Here we describe the BHC protocol, including aligning our MRI scans with those collected in the UK Biobank. We evaluate rates of research consent for the first 108 patients (data collection ongoing) and the ability of typical psychiatry-led NHS memory-clinic patients to tolerate both clinical and research assessments. ETHICS AND DISSEMINATION: Our ethics and consenting process enables patients to choose the level of research participation that suits them. This generates high rates of consent, enabling us to populate a research database with high-quality data that will be disseminated through a national platform (the Dementias Platform UK data portal). |
format | Online Article Text |
id | pubmed-10407419 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-104074192023-08-09 Oxford brain health clinic: protocol and research database O'Donoghue, Melissa Clare Blane, Jasmine Gillis, Grace Mitchell, Robert Lindsay, Karen Semple, Juliet Pretorius, Pieter M Griffanti, Ludovica Fossey, Jane Raymont, Vanessa Martos, Lola Mackay, Clare E BMJ Open Neurology INTRODUCTION: Despite major advances in the field of neuroscience over the last three decades, the quality of assessments available to patients with memory problems in later life has barely changed. At the same time, a large proportion of dementia biomarker research is conducted in selected research samples that often poorly reflect the demographics of the population of patients who present to memory clinics. The Oxford Brain Health Clinic (BHC) is a newly developed clinical assessment service with embedded research in which all patients are offered high-quality clinical and research assessments, including MRI, as standard. METHODS AND ANALYSIS: Here we describe the BHC protocol, including aligning our MRI scans with those collected in the UK Biobank. We evaluate rates of research consent for the first 108 patients (data collection ongoing) and the ability of typical psychiatry-led NHS memory-clinic patients to tolerate both clinical and research assessments. ETHICS AND DISSEMINATION: Our ethics and consenting process enables patients to choose the level of research participation that suits them. This generates high rates of consent, enabling us to populate a research database with high-quality data that will be disseminated through a national platform (the Dementias Platform UK data portal). BMJ Publishing Group 2023-08-04 /pmc/articles/PMC10407419/ /pubmed/37541753 http://dx.doi.org/10.1136/bmjopen-2022-067808 Text en © Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY. Published by BMJ. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Neurology O'Donoghue, Melissa Clare Blane, Jasmine Gillis, Grace Mitchell, Robert Lindsay, Karen Semple, Juliet Pretorius, Pieter M Griffanti, Ludovica Fossey, Jane Raymont, Vanessa Martos, Lola Mackay, Clare E Oxford brain health clinic: protocol and research database |
title | Oxford brain health clinic: protocol and research database |
title_full | Oxford brain health clinic: protocol and research database |
title_fullStr | Oxford brain health clinic: protocol and research database |
title_full_unstemmed | Oxford brain health clinic: protocol and research database |
title_short | Oxford brain health clinic: protocol and research database |
title_sort | oxford brain health clinic: protocol and research database |
topic | Neurology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10407419/ https://www.ncbi.nlm.nih.gov/pubmed/37541753 http://dx.doi.org/10.1136/bmjopen-2022-067808 |
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