Cargando…

Oxford brain health clinic: protocol and research database

INTRODUCTION: Despite major advances in the field of neuroscience over the last three decades, the quality of assessments available to patients with memory problems in later life has barely changed. At the same time, a large proportion of dementia biomarker research is conducted in selected research...

Descripción completa

Detalles Bibliográficos
Autores principales: O'Donoghue, Melissa Clare, Blane, Jasmine, Gillis, Grace, Mitchell, Robert, Lindsay, Karen, Semple, Juliet, Pretorius, Pieter M, Griffanti, Ludovica, Fossey, Jane, Raymont, Vanessa, Martos, Lola, Mackay, Clare E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10407419/
https://www.ncbi.nlm.nih.gov/pubmed/37541753
http://dx.doi.org/10.1136/bmjopen-2022-067808
_version_ 1785085957551161344
author O'Donoghue, Melissa Clare
Blane, Jasmine
Gillis, Grace
Mitchell, Robert
Lindsay, Karen
Semple, Juliet
Pretorius, Pieter M
Griffanti, Ludovica
Fossey, Jane
Raymont, Vanessa
Martos, Lola
Mackay, Clare E
author_facet O'Donoghue, Melissa Clare
Blane, Jasmine
Gillis, Grace
Mitchell, Robert
Lindsay, Karen
Semple, Juliet
Pretorius, Pieter M
Griffanti, Ludovica
Fossey, Jane
Raymont, Vanessa
Martos, Lola
Mackay, Clare E
author_sort O'Donoghue, Melissa Clare
collection PubMed
description INTRODUCTION: Despite major advances in the field of neuroscience over the last three decades, the quality of assessments available to patients with memory problems in later life has barely changed. At the same time, a large proportion of dementia biomarker research is conducted in selected research samples that often poorly reflect the demographics of the population of patients who present to memory clinics. The Oxford Brain Health Clinic (BHC) is a newly developed clinical assessment service with embedded research in which all patients are offered high-quality clinical and research assessments, including MRI, as standard. METHODS AND ANALYSIS: Here we describe the BHC protocol, including aligning our MRI scans with those collected in the UK Biobank. We evaluate rates of research consent for the first 108 patients (data collection ongoing) and the ability of typical psychiatry-led NHS memory-clinic patients to tolerate both clinical and research assessments. ETHICS AND DISSEMINATION: Our ethics and consenting process enables patients to choose the level of research participation that suits them. This generates high rates of consent, enabling us to populate a research database with high-quality data that will be disseminated through a national platform (the Dementias Platform UK data portal).
format Online
Article
Text
id pubmed-10407419
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher BMJ Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-104074192023-08-09 Oxford brain health clinic: protocol and research database O'Donoghue, Melissa Clare Blane, Jasmine Gillis, Grace Mitchell, Robert Lindsay, Karen Semple, Juliet Pretorius, Pieter M Griffanti, Ludovica Fossey, Jane Raymont, Vanessa Martos, Lola Mackay, Clare E BMJ Open Neurology INTRODUCTION: Despite major advances in the field of neuroscience over the last three decades, the quality of assessments available to patients with memory problems in later life has barely changed. At the same time, a large proportion of dementia biomarker research is conducted in selected research samples that often poorly reflect the demographics of the population of patients who present to memory clinics. The Oxford Brain Health Clinic (BHC) is a newly developed clinical assessment service with embedded research in which all patients are offered high-quality clinical and research assessments, including MRI, as standard. METHODS AND ANALYSIS: Here we describe the BHC protocol, including aligning our MRI scans with those collected in the UK Biobank. We evaluate rates of research consent for the first 108 patients (data collection ongoing) and the ability of typical psychiatry-led NHS memory-clinic patients to tolerate both clinical and research assessments. ETHICS AND DISSEMINATION: Our ethics and consenting process enables patients to choose the level of research participation that suits them. This generates high rates of consent, enabling us to populate a research database with high-quality data that will be disseminated through a national platform (the Dementias Platform UK data portal). BMJ Publishing Group 2023-08-04 /pmc/articles/PMC10407419/ /pubmed/37541753 http://dx.doi.org/10.1136/bmjopen-2022-067808 Text en © Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY. Published by BMJ. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/.
spellingShingle Neurology
O'Donoghue, Melissa Clare
Blane, Jasmine
Gillis, Grace
Mitchell, Robert
Lindsay, Karen
Semple, Juliet
Pretorius, Pieter M
Griffanti, Ludovica
Fossey, Jane
Raymont, Vanessa
Martos, Lola
Mackay, Clare E
Oxford brain health clinic: protocol and research database
title Oxford brain health clinic: protocol and research database
title_full Oxford brain health clinic: protocol and research database
title_fullStr Oxford brain health clinic: protocol and research database
title_full_unstemmed Oxford brain health clinic: protocol and research database
title_short Oxford brain health clinic: protocol and research database
title_sort oxford brain health clinic: protocol and research database
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10407419/
https://www.ncbi.nlm.nih.gov/pubmed/37541753
http://dx.doi.org/10.1136/bmjopen-2022-067808
work_keys_str_mv AT odonoghuemelissaclare oxfordbrainhealthclinicprotocolandresearchdatabase
AT blanejasmine oxfordbrainhealthclinicprotocolandresearchdatabase
AT gillisgrace oxfordbrainhealthclinicprotocolandresearchdatabase
AT mitchellrobert oxfordbrainhealthclinicprotocolandresearchdatabase
AT lindsaykaren oxfordbrainhealthclinicprotocolandresearchdatabase
AT semplejuliet oxfordbrainhealthclinicprotocolandresearchdatabase
AT pretoriuspieterm oxfordbrainhealthclinicprotocolandresearchdatabase
AT griffantiludovica oxfordbrainhealthclinicprotocolandresearchdatabase
AT fosseyjane oxfordbrainhealthclinicprotocolandresearchdatabase
AT raymontvanessa oxfordbrainhealthclinicprotocolandresearchdatabase
AT martoslola oxfordbrainhealthclinicprotocolandresearchdatabase
AT mackayclaree oxfordbrainhealthclinicprotocolandresearchdatabase