Cargando…
Tohoku Medical Megabank Brain Magnetic Resonance Imaging Study: Rationale, Design, and Background
The Tohoku Medical Megabank Brain Magnetic Resonance Imaging Study (TMM Brain MRI Study) was established to collect multimodal information through neuroimaging and neuropsychological assessments to evaluate the cognitive function and mental health of residents who experienced the Great East Japan Ea...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Japan Medical Association
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10407421/ https://www.ncbi.nlm.nih.gov/pubmed/37560377 http://dx.doi.org/10.31662/jmaj.2022-0220 |
_version_ | 1785085958019874816 |
---|---|
author | Taira, Makiko Mugikura, Shunji Mori, Naoko Hozawa, Atsushi Saito, Tomo Nakamura, Tomohiro Kiyomoto, Hideyasu Kobayashi, Tadao Ogishima, Soichi Nagami, Fuji Uruno, Akira Shimizu, Ritsuko Kobayashi, Tomoko Yasuda, Jun Kure, Shigeo Sakurai, Miyuki Motoike, Ikuko N. Kumada, Kazuki Nakaya, Naoki Obara, Taku Oba, Kentaro Sekiguchi, Atsushi Thyreau, Benjamin Mutoh, Tatsushi Takano, Yuji Abe, Mitsunari Maikusa, Norihide Tatewaki, Yasuko Taki, Yasuyuki Yaegashi, Nobuo Tomita, Hiroaki Kinoshita, Kengo Kuriyama, Shinichi Fuse, Nobuo Yamamoto, Masayuki |
author_facet | Taira, Makiko Mugikura, Shunji Mori, Naoko Hozawa, Atsushi Saito, Tomo Nakamura, Tomohiro Kiyomoto, Hideyasu Kobayashi, Tadao Ogishima, Soichi Nagami, Fuji Uruno, Akira Shimizu, Ritsuko Kobayashi, Tomoko Yasuda, Jun Kure, Shigeo Sakurai, Miyuki Motoike, Ikuko N. Kumada, Kazuki Nakaya, Naoki Obara, Taku Oba, Kentaro Sekiguchi, Atsushi Thyreau, Benjamin Mutoh, Tatsushi Takano, Yuji Abe, Mitsunari Maikusa, Norihide Tatewaki, Yasuko Taki, Yasuyuki Yaegashi, Nobuo Tomita, Hiroaki Kinoshita, Kengo Kuriyama, Shinichi Fuse, Nobuo Yamamoto, Masayuki |
author_sort | Taira, Makiko |
collection | PubMed |
description | The Tohoku Medical Megabank Brain Magnetic Resonance Imaging Study (TMM Brain MRI Study) was established to collect multimodal information through neuroimaging and neuropsychological assessments to evaluate the cognitive function and mental health of residents who experienced the Great East Japan Earthquake (GEJE) and associated tsunami. The study also aimed to promote advances in personalized healthcare and medicine related to mental health and cognitive function among the general population. We recruited participants for the first (baseline) survey starting in July 2014, enrolling individuals who were participating in either the TMM Community-Based Cohort Study (TMM CommCohort Study) or the TMM Birth and Three-Generation Cohort Study (TMM BirThree Cohort Study). We collected multiple magnetic resonance imaging (MRI) sequences, including 3D T1-weighted sequences, magnetic resonance angiography (MRA), diffusion tensor imaging (DTI), pseudo-continuous arterial spin labeling (pCASL), and three-dimensional fluid-attenuated inversion recovery (FLAIR) sequences. To assess neuropsychological status, we used both questionnaire- and interview-based rating scales. The former assessments included the Tri-axial Coping Scale, Impact of Event Scale in Japanese, Profile of Mood States, and 15-item Depression, Anxiety, and Stress Scale, whereas the latter assessments included the Mini-Mental State Examination, Japanese version. A total of 12,164 individuals were recruited for the first (baseline) survey, including those unable to complete all assessments. In parallel, we returned the MRI results to the participants and subsequently shared the MRI data through the TMM Biobank. At present, the second (first follow-up) survey of the study started in October 2019 is underway. In this study, we established a large and comprehensive database that included robust neuroimaging data as well as psychological and cognitive assessment data. In combination with genomic and omics data already contained in the TMM Biobank database, these data could provide new insights into the relationships of pathological processes with neuropsychological disorders, including age-related cognitive impairment. |
format | Online Article Text |
id | pubmed-10407421 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Japan Medical Association |
record_format | MEDLINE/PubMed |
spelling | pubmed-104074212023-08-09 Tohoku Medical Megabank Brain Magnetic Resonance Imaging Study: Rationale, Design, and Background Taira, Makiko Mugikura, Shunji Mori, Naoko Hozawa, Atsushi Saito, Tomo Nakamura, Tomohiro Kiyomoto, Hideyasu Kobayashi, Tadao Ogishima, Soichi Nagami, Fuji Uruno, Akira Shimizu, Ritsuko Kobayashi, Tomoko Yasuda, Jun Kure, Shigeo Sakurai, Miyuki Motoike, Ikuko N. Kumada, Kazuki Nakaya, Naoki Obara, Taku Oba, Kentaro Sekiguchi, Atsushi Thyreau, Benjamin Mutoh, Tatsushi Takano, Yuji Abe, Mitsunari Maikusa, Norihide Tatewaki, Yasuko Taki, Yasuyuki Yaegashi, Nobuo Tomita, Hiroaki Kinoshita, Kengo Kuriyama, Shinichi Fuse, Nobuo Yamamoto, Masayuki JMA J Review Article The Tohoku Medical Megabank Brain Magnetic Resonance Imaging Study (TMM Brain MRI Study) was established to collect multimodal information through neuroimaging and neuropsychological assessments to evaluate the cognitive function and mental health of residents who experienced the Great East Japan Earthquake (GEJE) and associated tsunami. The study also aimed to promote advances in personalized healthcare and medicine related to mental health and cognitive function among the general population. We recruited participants for the first (baseline) survey starting in July 2014, enrolling individuals who were participating in either the TMM Community-Based Cohort Study (TMM CommCohort Study) or the TMM Birth and Three-Generation Cohort Study (TMM BirThree Cohort Study). We collected multiple magnetic resonance imaging (MRI) sequences, including 3D T1-weighted sequences, magnetic resonance angiography (MRA), diffusion tensor imaging (DTI), pseudo-continuous arterial spin labeling (pCASL), and three-dimensional fluid-attenuated inversion recovery (FLAIR) sequences. To assess neuropsychological status, we used both questionnaire- and interview-based rating scales. The former assessments included the Tri-axial Coping Scale, Impact of Event Scale in Japanese, Profile of Mood States, and 15-item Depression, Anxiety, and Stress Scale, whereas the latter assessments included the Mini-Mental State Examination, Japanese version. A total of 12,164 individuals were recruited for the first (baseline) survey, including those unable to complete all assessments. In parallel, we returned the MRI results to the participants and subsequently shared the MRI data through the TMM Biobank. At present, the second (first follow-up) survey of the study started in October 2019 is underway. In this study, we established a large and comprehensive database that included robust neuroimaging data as well as psychological and cognitive assessment data. In combination with genomic and omics data already contained in the TMM Biobank database, these data could provide new insights into the relationships of pathological processes with neuropsychological disorders, including age-related cognitive impairment. Japan Medical Association 2023-06-30 2023-07-14 /pmc/articles/PMC10407421/ /pubmed/37560377 http://dx.doi.org/10.31662/jmaj.2022-0220 Text en Copyright © Japan Medical Association https://creativecommons.org/licenses/by/4.0/JMA Journal is an Open Access journal distributed under the Creative Commons Attribution 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Article Taira, Makiko Mugikura, Shunji Mori, Naoko Hozawa, Atsushi Saito, Tomo Nakamura, Tomohiro Kiyomoto, Hideyasu Kobayashi, Tadao Ogishima, Soichi Nagami, Fuji Uruno, Akira Shimizu, Ritsuko Kobayashi, Tomoko Yasuda, Jun Kure, Shigeo Sakurai, Miyuki Motoike, Ikuko N. Kumada, Kazuki Nakaya, Naoki Obara, Taku Oba, Kentaro Sekiguchi, Atsushi Thyreau, Benjamin Mutoh, Tatsushi Takano, Yuji Abe, Mitsunari Maikusa, Norihide Tatewaki, Yasuko Taki, Yasuyuki Yaegashi, Nobuo Tomita, Hiroaki Kinoshita, Kengo Kuriyama, Shinichi Fuse, Nobuo Yamamoto, Masayuki Tohoku Medical Megabank Brain Magnetic Resonance Imaging Study: Rationale, Design, and Background |
title | Tohoku Medical Megabank Brain Magnetic Resonance Imaging Study: Rationale, Design, and Background |
title_full | Tohoku Medical Megabank Brain Magnetic Resonance Imaging Study: Rationale, Design, and Background |
title_fullStr | Tohoku Medical Megabank Brain Magnetic Resonance Imaging Study: Rationale, Design, and Background |
title_full_unstemmed | Tohoku Medical Megabank Brain Magnetic Resonance Imaging Study: Rationale, Design, and Background |
title_short | Tohoku Medical Megabank Brain Magnetic Resonance Imaging Study: Rationale, Design, and Background |
title_sort | tohoku medical megabank brain magnetic resonance imaging study: rationale, design, and background |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10407421/ https://www.ncbi.nlm.nih.gov/pubmed/37560377 http://dx.doi.org/10.31662/jmaj.2022-0220 |
work_keys_str_mv | AT tairamakiko tohokumedicalmegabankbrainmagneticresonanceimagingstudyrationaledesignandbackground AT mugikurashunji tohokumedicalmegabankbrainmagneticresonanceimagingstudyrationaledesignandbackground AT morinaoko tohokumedicalmegabankbrainmagneticresonanceimagingstudyrationaledesignandbackground AT hozawaatsushi tohokumedicalmegabankbrainmagneticresonanceimagingstudyrationaledesignandbackground AT saitotomo tohokumedicalmegabankbrainmagneticresonanceimagingstudyrationaledesignandbackground AT nakamuratomohiro tohokumedicalmegabankbrainmagneticresonanceimagingstudyrationaledesignandbackground AT kiyomotohideyasu tohokumedicalmegabankbrainmagneticresonanceimagingstudyrationaledesignandbackground AT kobayashitadao tohokumedicalmegabankbrainmagneticresonanceimagingstudyrationaledesignandbackground AT ogishimasoichi tohokumedicalmegabankbrainmagneticresonanceimagingstudyrationaledesignandbackground AT nagamifuji tohokumedicalmegabankbrainmagneticresonanceimagingstudyrationaledesignandbackground AT urunoakira tohokumedicalmegabankbrainmagneticresonanceimagingstudyrationaledesignandbackground AT shimizuritsuko tohokumedicalmegabankbrainmagneticresonanceimagingstudyrationaledesignandbackground AT kobayashitomoko tohokumedicalmegabankbrainmagneticresonanceimagingstudyrationaledesignandbackground AT yasudajun tohokumedicalmegabankbrainmagneticresonanceimagingstudyrationaledesignandbackground AT kureshigeo tohokumedicalmegabankbrainmagneticresonanceimagingstudyrationaledesignandbackground AT sakuraimiyuki tohokumedicalmegabankbrainmagneticresonanceimagingstudyrationaledesignandbackground AT motoikeikukon tohokumedicalmegabankbrainmagneticresonanceimagingstudyrationaledesignandbackground AT kumadakazuki tohokumedicalmegabankbrainmagneticresonanceimagingstudyrationaledesignandbackground AT nakayanaoki tohokumedicalmegabankbrainmagneticresonanceimagingstudyrationaledesignandbackground AT obarataku tohokumedicalmegabankbrainmagneticresonanceimagingstudyrationaledesignandbackground AT obakentaro tohokumedicalmegabankbrainmagneticresonanceimagingstudyrationaledesignandbackground AT sekiguchiatsushi tohokumedicalmegabankbrainmagneticresonanceimagingstudyrationaledesignandbackground AT thyreaubenjamin tohokumedicalmegabankbrainmagneticresonanceimagingstudyrationaledesignandbackground AT mutohtatsushi tohokumedicalmegabankbrainmagneticresonanceimagingstudyrationaledesignandbackground AT takanoyuji tohokumedicalmegabankbrainmagneticresonanceimagingstudyrationaledesignandbackground AT abemitsunari tohokumedicalmegabankbrainmagneticresonanceimagingstudyrationaledesignandbackground AT maikusanorihide tohokumedicalmegabankbrainmagneticresonanceimagingstudyrationaledesignandbackground AT tatewakiyasuko tohokumedicalmegabankbrainmagneticresonanceimagingstudyrationaledesignandbackground AT takiyasuyuki tohokumedicalmegabankbrainmagneticresonanceimagingstudyrationaledesignandbackground AT yaegashinobuo tohokumedicalmegabankbrainmagneticresonanceimagingstudyrationaledesignandbackground AT tomitahiroaki tohokumedicalmegabankbrainmagneticresonanceimagingstudyrationaledesignandbackground AT kinoshitakengo tohokumedicalmegabankbrainmagneticresonanceimagingstudyrationaledesignandbackground AT kuriyamashinichi tohokumedicalmegabankbrainmagneticresonanceimagingstudyrationaledesignandbackground AT fusenobuo tohokumedicalmegabankbrainmagneticresonanceimagingstudyrationaledesignandbackground AT yamamotomasayuki tohokumedicalmegabankbrainmagneticresonanceimagingstudyrationaledesignandbackground |