Repair of topoisomerase 1–induced DNA damage by tyrosyl-DNA phosphodiesterase 2 (TDP2) is dependent on its magnesium binding

Topoisomerases are enzymes that relax DNA supercoiling during replication and transcription. Camptothecin, a topoisomerase 1 (TOP1) inhibitor, and its analogs trap TOP1 at the 3′-end of DNA as a DNA-bound intermediate, resulting in DNA damage that can kill cells. Drugs with this mechanism of action...

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Detalles Bibliográficos
Autores principales: Shimizu, Naoto, Hamada, Yusaku, Morozumi, Ryosuke, Yamamoto, Junpei, Iwai, Shigenori, Sugiyama, Kei-ichi, Ide, Hiroshi, Tsuda, Masataka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article Collection: Structural and Enzymatic Insights into Chromatin Regulatory Machines
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10407441/
https://www.ncbi.nlm.nih.gov/pubmed/37392847
http://dx.doi.org/10.1016/j.jbc.2023.104988

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