The NLRP3 inflammasome in viral infection (Review)

The interplay between pathogen and host determines the immune response during viral infection. The Nod-like receptor (NLR) protein 3 inflammasome is a multiprotein complex that induces the activation of inflammatory caspases and the release of IL-1β, which play an important role in the innate immune...

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Detalles Bibliográficos
Autores principales: Zheng, Qiaoli, Hua, Chunting, Liang, Qichang, Cheng, Hao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10407610/
https://www.ncbi.nlm.nih.gov/pubmed/37417336
http://dx.doi.org/10.3892/mmr.2023.13047
Descripción
Sumario:The interplay between pathogen and host determines the immune response during viral infection. The Nod-like receptor (NLR) protein 3 inflammasome is a multiprotein complex that induces the activation of inflammatory caspases and the release of IL-1β, which play an important role in the innate immune responses. In the present review, the mechanisms of the NLR family pyrin domain containing 3 inflammasome activation and its dysregulation in viral infection were addressed.

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